Related Products of 13078-91-6, A common heterocyclic compound, 13078-91-6, name is 2-(Indolin-3-yl)ethanamine, molecular formula is C10H14N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of tyrptamine (Ig, 6.25mmol) in DCM (lOmi) was added TFA (2m1) followed by sodium borohydride (475mg, 12.5mmol) and stirred overnight. The mixture was diluted with DCM and neutralised with sat. Na2CO3(aq). The organic phase wasseparated1 dried and concentrated to give 2-indolin-3-ylethanamine, a yellow oil. This was taken up in DCM (3Oml), triethylamine (0.90ml, 6.2mmol) added followed by BOC anhydride (1 .35g, 6.2mmol) and stirred overnight. The mixture was diluted with DCM and water. The organic layer separated, dried and concentrated onto silica. The compound was purified via column chromatography (gradient elution from 5-25%EtOAc in Pet. Ether) to give a yellow oil (684mg, 42%); 1H NMR (400 MHz,CHLOROFORM-cl) oe ppm 1.46 (s, 9K), 1.72 (m, I H), 1.90-2.04 (m, 1 H), 3.15-3.28(m, 2 H), 3.28 – 3.41 (m, 1 H), 3.58 – 3.77 (m, 1 H), 4.06 – 4.11 (m, I H), 4.57 (m, 1 H),6.90 – 6,99 (m, I H), 7.08 – 7.22 (m, 2 H), 7.37 – 8.06 (m, 1 H); LC-MS (ESl): (MW)263.2
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.