Category: 126674-93-9

Some tips on C8H3F2NO2

Some common heterocyclic compound, 126674-93-9, name is 4,6-Difluoro-1H-indole-2,3-dione, molecular formula is C8H3F2NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 4,6-Difluoro-1H-indole-2,3-dione

Some common heterocyclic compound, 126674-93-9, name is 4,6-Difluoro-1H-indole-2,3-dione, molecular formula is C8H3F2NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 4,6-Difluoro-1H-indole-2,3-dione

Stage 3: 2-amino-4,6-difluorobenzoic acid First sodium hydroxide (6.70 g, 167 mmol) and then 30% hydrogen peroxide (6.7 ml) in water (60 ml) were added to a suspension of the product from stage 2 (4.58 g, 25 mmol) in water (125 ml) at 0 C. The mixture was stirred at room temperature for 20 h and then brought to pH 3 with formic acid (approx. 11 ml, severe foaming), during which the title compound precipitated out. The mixture was then filtered and product was dried over phosphorus pentoxide in a desiccator. Yield: 3.72 g (86%), white solid. Melting point: 198-202 C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 126674-93-9, its application will become more common.

Reference:
Patent; Gruenenthal GmbH; US2008/293749; (2008); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Introduction of a new synthetic route about 126674-93-9

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4,6-Difluoro-1H-indole-2,3-dione, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 126674-93-9, name is 4,6-Difluoro-1H-indole-2,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 126674-93-9, Formula: C8H3F2NO2

[Reference Example 154] (0739) (0740) To the solution of 250 mg of 4,6-difluoro-1H-indole-2,3-dione in 3 mL of sulfuric acid, 109 muL of 60% nitric acid was added dropwise at -20C, and the resultant was stirred for 15 minutes. Water was added dropwise to the reaction mixture, followed by addition of ethyl acetate. The organic layer was separated, sequentially washed with a saturated aqueous sodium bicarbonate solution and a saturated aqueous sodium chloride solution and dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The obtained residue was purified by silica gel column chromatography (gradient elution with hexane:ethyl acetate) to give 180 mg of 4,6-difluoro-5-nitro-1H-indole-2,3-dione as a yellow solid. 1H-NMR (DMSO-d6) delta: 6.95 (1H, d, J = 10.6 Hz), 11.95 (1H, s) MS (ESI, m/z): 227 (M-H)-.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4,6-Difluoro-1H-indole-2,3-dione, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Toyama Chemical Co., Ltd.; FUJIFILM Corporation; TANAKA, Tadashi; KONISHI, Yoshitake; KUBO, Daisuke; FUJINO, Masataka; DOI, Issei; NAKAGAWA, Daisuke; MURAKAMI, Tatsuya; YAMAKAWA, Takayuki; EP2915804; (2015); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem