Category: 1168150-46-6

1168150-46-6, name is (E)-Methyl 3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 1168150-46-6

(3) Preparation of methyl (Z)-3-((1-(2-(dimethylamino) acetyl)indolin-5-ylamino)(phenyl)methylene)-2-oxoindoline-6-carboxylate and its hydrochloride1-(2-(dimethylamino) acetyl)-5-aminoindoline (0.082g, 0.3mmol) and methyl (E)-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate (0.086g, 0.28mmol) was added to MeOH (2ml). The resulting mixture was heated to 70 C and kept for 7 hours. After being cooled naturally, the mixture was filtered by suction. The filtrate was dried to produce a yellow solid (61mg) in a yield of 35.4%.Methanol (10ml) was added to a concentrated hydrochloric acid (1ml). The above crude product was added to the resulting solution. The mixture was stirred at room temperature for 2 hours, and filtered by suction. The filtrate was dried in vacuum to produce methyl (Z)-3-((1-(2-(dimethylamino) acetyl)indolin-5-ylamino)(phenyl)methylene)-2oxoindoline-6-carboxylate hydrochloride (68mg) as a yellow solid. Formula: C29H28N4O4; MW: 496.2; Mass Spectrum (m/e): 497.3 (M+1) 1H NMR (400MHz; hydrochloride, DMSO-d6, deltappm) ? 12.16 (s, 1H), 10.96 (s, 1H), 9.77 (br. s., 1H), 7.79 (d, J = 8.8 1H), 7.56 (m, 3H), 7.45 (m, 2H), 7.26 (s, 1H), 7.17(m, 1H), 6.88 (s, 1H), 6.74 (s, 1H), 5.81(d, J = 8.4, 1H), 4.25 (m, 2H), 3.96(m, 2H), 3.76 (s, 3H), 3.04 (m, 2H), 2.83 (m, 6H).

Statistics shows that 1168150-46-6 is playing an increasingly important role. we look forward to future research findings about (E)-Methyl 3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate.

Reference:
Patent; KBP Biosciences Co., Ltd.; LO, Hoyin; WANG, Aichen; ZHANG, Qian; EP2930167; (2015); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

1168150-46-6, The chemical industry reduces the impact on the environment during synthesis 1168150-46-6, name is (E)-Methyl 3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate, I believe this compound will play a more active role in future production and life.

General procedure: A mixture of intermediate (3a, 3b, 6a, 6b, 10a, 10b, 11a-d, and14a-g, 1.5 mmol) and methyl (E)-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate (1.5 mmol) in methanol (10 mL) wasstirred under reflux for 5-10 h. When TLC showed the completionof the reaction, the solution was cooled to room temperature. Theprecipitate was filtered off to give a crude product, which wasrecrystallized from methanol to provide the target compounds.

The chemical industry reduces the impact on the environment during synthesis (E)-Methyl 3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate. I believe this compound will play a more active role in future production and life.

Reference:
Article; Qin, Mingze; Tian, Ye; Sun, Xiaoqing; Yu, Simiao; Xia, Juanjuan; Gong, Ping; Zhang, Haotian; Zhao, Yanfang; European Journal of Medicinal Chemistry; vol. 139; (2017); p. 492 – 502;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

These common heterocyclic compound, 1168150-46-6, name is (E)-Methyl 3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 1168150-46-6

General procedure: A mixture of intermediate (3a, 3b, 6a, 6b, 10a, 10b, 11a-d, and14a-g, 1.5 mmol) and methyl (E)-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate (1.5 mmol) in methanol (10 mL) wasstirred under reflux for 5-10 h. When TLC showed the completionof the reaction, the solution was cooled to room temperature. Theprecipitate was filtered off to give a crude product, which wasrecrystallized from methanol to provide the target compounds.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1168150-46-6.

Reference:
Article; Qin, Mingze; Tian, Ye; Sun, Xiaoqing; Yu, Simiao; Xia, Juanjuan; Gong, Ping; Zhang, Haotian; Zhao, Yanfang; European Journal of Medicinal Chemistry; vol. 139; (2017); p. 492 – 502;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem