Category: 1127-59-9

In chemical reaction engineering, simulations are useful for investigating and optimizing a particular reaction process or system., Product Details of 1127-59-9

General procedure: Compound B (11.9 mg, 0.02 mmol) was added at 4 C in a mixed solution of Eosin 1a (29.4 mg, 0.2 mmol) and methyl acetoacetate 2a (107.8 muL, 1.0 mmol) in tetrahydrofuran (1.0 mL). The reaction was stirred at 4 C for 96 hours. Spin-drying, column chromatography (petrole ether: ethyl acetate = 1 : 1-1 : 2), and evaporated to give a pale yellow amorphous solid 49.0mg, yield 93%, 90% ee.

We very much hope you enjoy reading the articles and that you will join us to present your own research about 7-Methylindoline-2,3-dione.

Reference:
Patent; Anhui University of Technology; Zhang Dongxin; Yin Lei; Zhong Junchao; Man Jingjing; Chen Yan; Zhang Qianfeng; (21 pag.)CN110041243; (2019); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Redox catalysis has been broadly utilized in electrochemical synthesis. The appropriate choice of redox mediator can avoid electrode passivation and overpotential, which strongly inhibit the efficient activation of substrates in electrolysis., Reference of 1127-59-9

8-Methyl-2-(2-pyridyl)quinoline-4-carboxylic acid (VI; R1 =2′-aza, R2 =H) A mixture of 2-acetylpyridine (IV; R1 =2-aza: 6.05 g, 0.05 mol) and 7-methylisatin (V; R2 =H: 8.52 g, 0.053 mol) in 65 mL of 50percent EtOH–H2 O containing KOH (13 g) was refluxed for 2 h, then diluted with 50percent EtOH–H2 O to obtain a homogeneous solution, filtered and acidified (HOAc). The resulting acid was collected, washed with 30percent EtOH–H2 O and recrystallized from DMF–EtOH to provide the product (9.4 g, 67percent, mp. 319°-320° C. Anal. (C16 H12 N2 O2) C,H,N. Similar reactions using appropriately substituted acetophenones gave the 8-methyl-2-phenylquinoline-4-carboxylic acids (VI) listed in Table III.

Future efforts will undeniably focus on the diversification of the new catalytic transformations. These may comprise an expansion of the substrate scope from aromatic and heteroaromatic compounds to other hydrocarbons. Keep reading other articles of 1127-59-9.

Reference:
Patent; Development Finance Corporation of New Zeland; US4904659; (1990); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1127-59-9 as follows. Related Products of 1127-59-9

Mg(ClO4)2 (0.1 g) was added to a mixture of isatin (2 mmol), and dimedone (4 mmol) in aqueousethanol solution (50percent, v/v, 5 mL), and the resulting mixture was stirred at 80°C for 10?12 h. Upon completion of the reaction (TLC, Ethyl acetate/Petroleum ether = 1:4), the mixture was allowedto cool to room temperature. The resulting solid was filtered and washed successively with water(2 30 mL) and cold aqueous ethanol (2 1 mL) to afford a crude product, which was recrystallizedfrom EtOH to afford the pure product 3. Some insolubility could be observed in the refluxing ethanolduring the recrystallization process, which should be filtered when hot.

You can get involved in discussing the latest developments in this exciting area about 7-Methylindoline-2,3-dione.

Reference:
Article; Chen, Chunfeng; Lv, Chunlei; Liang, Jianfeng; Jin, Jianqing; Wang, Lijun; Wu, Chunlei; Shen, Runpu; Molecules; vol. 22; 8; (2017);,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1127-59-9, name is 7-Methylindoline-2,3-dione, A new synthetic method of this compound is introduced below., 1127-59-9

General procedure: A mixture of 1H-pyrazol-5-amin (1 mmol), isatin (1 mmol) and enolizable C ? H activated compound (1 mmol) in NDDES (1.5 ml)was stirred under microwave irradiation at 60°C for an appropriate time. The progress of the reaction was monitored by TLC. After completion of the reaction, the mixture was cooled to room temperature and cold water was added to the reaction mixture. The precipitated solid was isolated by filtration, washed with water and purified by recrystallization from ethanol.

Future efforts will undeniably focus on the diversification of the new catalytic transformations. These may comprise an expansion of the substrate scope from aromatic and heteroaromatic compounds to other hydrocarbons. Keep reading other articles of 1127-59-9.

Reference:
Article; Zhang, Wei-Hong; Chen, Meng-Nan; Hao, Yi; Jiang, Xin; Zhou, Xiao-Lin; Zhang, Zhan-Hui; Journal of Molecular Liquids; vol. 278; (2019); p. 124 – 129;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Recommanded Product: 1127-59-9, The prevalence of solvent effects in heterogeneous catalysis has motivated developing quantitative kinetic, spectroscopic, and theoretical assessments of solvent structures and their interactions with reaction intermediates and transition states.

General procedure: Mg(ClO4)2 (10 mol %) was added to a mixture of isatin (2 mmol), malononitrile or ethyl cyanoacetate (2mmol), and dimedone (2 mmol) in aqueous ethanol solution(50%, v/v, 5 mL), and the resulting mixture was stirred at 50C for 30-60 min. Upon completion of the reaction (TLC),the mixture was allowed to cool to room temperature. The resulting solid was filtered and washed successively with water (2 × 30 mL) and cold aqueous ethanol (2 × 1 mL) to afford pure product 4.

According to the analysis of related databases, 1127-59-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Wu, Chunlei; Shen, Runpu; Chen, Jianhui; Hu, Chunqi; Bulletin of the Korean Chemical Society; vol. 34; 8; (2013); p. 2431 – 2435;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1127-59-9, name is 7-Methylindoline-2,3-dione, This compound has unique chemical properties. The synthetic route is as follows., category: indolines-derivatives

A solution of 7-methylindoline-2,3-dione (7.08 g, 44 mmol), NaOH (1.77 g, 44 mmol) and KCl (7.08 g, 95 mmol) in water (80ml) was cooled to 0 C and 33% H2O2 (6.02 mL, 0.66 mmol) was added dropwise over 1.5 hours. After an additional 45 minutes at room temperature the addition of acetic acid (16 mL) caused precipitation of the product. Recrystallization from water gave the title compound (5.26 g, 80%) as a pale brown solid. mp 162 – 164 C (Litt7. 174 – 176 C). 1H NMR (300 MHz, DMSO-d6) delta 7.61 (dd, J = 8.0, 1.3 Hz, 1H), 7.13 (dd, J = 7.1, 1.3 Hz, 1H), 6.45 (dd, J = 8.0, 7.1 Hz, 1H), 2.10 (s, 3H). 13C NMR (75 MHz, DMSO-d6) delta 169.9, 149.6, 134.3, 129.0, 122.9, 114.3, 109.3, 17.7

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1127-59-9.

Reference:
Article; Hansen, Martin; Jacobsen, Stine Engesgaard; Plunkett, Shane; Liebscher, Gudrun Eckhard; McCorvy, John D.; Braeuner-Osborne, Hans; Kristensen, Jesper Langgaard; Bioorganic and Medicinal Chemistry; vol. 23; 14; (2015); p. 3933 – 3937;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1127-59-9, name is 7-Methylindoline-2,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1127-59-9, Formula: C9H7NO2

General procedure: Compound B (11.9 mg, 0.02 mmol) was added at 4 C in a mixed solution of Eosin 1a (29.4 mg, 0.2 mmol) and methyl acetoacetate 2a (107.8 muL, 1.0 mmol) in tetrahydrofuran (1.0 mL). The reaction was stirred at 4 C for 96 hours. Spin-drying, column chromatography (petrole ether: ethyl acetate = 1 : 1-1 : 2), and evaporated to give a pale yellow amorphous solid 49.0mg, yield 93%, 90% ee.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 7-Methylindoline-2,3-dione, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Anhui University of Technology; Zhang Dongxin; Yin Lei; Zhong Junchao; Man Jingjing; Chen Yan; Zhang Qianfeng; (21 pag.)CN110041243; (2019); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Reference of 1127-59-9, These common heterocyclic compound, 1127-59-9, name is 7-Methylindoline-2,3-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: 0.31 g (1.1 mmol) of 3,5-di-tert-butyl-4-hydroxybenzyl acetate 14 and 0.03 mL of triethyl-amine were added to a continuously stirred solution of the isatin derivative 1?13 (1 mmol) in DMF. The reaction was performed at 70°, completion of the reaction of the reactants was determined by TLC. After cooling to ambient, the reaction mixture was poured into a brine. The obtained precipitate was filtered off, washed with water, and dried in vacuum (12 mmHg).

The synthetic route of 1127-59-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Bogdanov; Zaripova; Voloshina; Strobykina; Kulik; Bukharov; Mironov; Russian Journal of General Chemistry; vol. 88; 1; (2018); p. 57 – 67; Zh. Obshch. Khim.; vol. 88; 1; (2018); p. 61 – 71,11;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Related Products of 1127-59-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1127-59-9, name is 7-Methylindoline-2,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.

8-Methyl-2-(2-pyridyl)quinoline-4-carboxylic acid (VI; R1 =2′-aza, R2 =H) A mixture of 2-acetylpyridine (IV; R1 =2-aza: 6.05 g, 0.05 mol) and 7-methylisatin (V; R2 =H: 8.52 g, 0.053 mol) in 65 mL of 50percent EtOH–H2 O containing KOH (13 g) was refluxed for 2 h, then diluted with 50percent EtOH–H2 O to obtain a homogeneous solution, filtered and acidified (HOAc). The resulting acid was collected, washed with 30percent EtOH–H2 O and recrystallized from DMF–EtOH to provide the product (9.4 g, 67percent, mp. 319°-320° C. Anal. (C16 H12 N2 O2) C,H,N. Similar reactions using appropriately substituted acetophenones gave the 8-methyl-2-phenylquinoline-4-carboxylic acids (VI) listed in Table III.

The synthetic route of 7-Methylindoline-2,3-dione has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Development Finance Corporation of New Zeland; US4904659; (1990); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1127-59-9, name is 7-Methylindoline-2,3-dione, This compound has unique chemical properties. The synthetic route is as follows., Safety of 7-Methylindoline-2,3-dione

General procedure: A mixture of 1H-pyrazol-5-amin (1 mmol), isatin (1 mmol) and enolizable C ? H activated compound (1 mmol) in NDDES (1.5 ml)was stirred under microwave irradiation at 60°C for an appropriate time. The progress of the reaction was monitored by TLC. After completion of the reaction, the mixture was cooled to room temperature and cold water was added to the reaction mixture. The precipitated solid was isolated by filtration, washed with water and purified by recrystallization from ethanol.

According to the analysis of related databases, 1127-59-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Zhang, Wei-Hong; Chen, Meng-Nan; Hao, Yi; Jiang, Xin; Zhou, Xiao-Lin; Zhang, Zhan-Hui; Journal of Molecular Liquids; vol. 278; (2019); p. 124 – 129;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem