Category: 1074-82-4

A common compound: 1074-82-4, name is Potassium 1,3-dioxoisoindolin-2-ide, belongs to indolines-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 1074-82-4

8.7ml (6 ¡¤ 5 X 102 moles) 1,5-dibromopentane with6 g (3. 2 X 10 2 moles) Phthalimide potassium salt dissolved in 100ml of N, N- dimethylformamide andunder room temperatureit was stirred for 15hours.The solvent was distilled off under reduced pressure, The residue usingn-hexane: ethyl acetate with a volumeratio of 10: 1 eluent to carry out column chromatography, gradually increasingthe polarity to hexane: ethyl acetate with a volume ratio of 5: 1 to give a product of 6.9g(2.3X102 mol) a bromogroup substituted by Phthalimide. The product with 5. 9g (4. 7X 102 mol) of sodium sulfite, 140ml water and 85ml95% ethanol mixed reactionwas heated to 95 C for18h, the remainingsolvent was drained, and the resulting residue was mixed with 73ml ofconcentrated hydrochloric acidthen was heated to 110 C thefor 18H, it was drained, with water – 95% ethanol on the residue to carry out recrystallization to give 5-amino-1-pentylSulfonic acid 2. 7g (total yield 50%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1074-82-4, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Institute of Chemistry Chinese Academy of Sciences; zhao, jingquan; DENG, HONG; XEI, JIE; (16 pag.)CN101948412; (2016); B;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

These common heterocyclic compound, 1074-82-4, name is Potassium 1,3-dioxoisoindolin-2-ide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 1074-82-4

20ml (1.3X 10 1 mol) 1,6-dibromopentane with 8 g (4.3X 10 2moles) Phthalimide potassium salt dissolved in 100ml of N, N- dimethylformamideand under room temperature it was stirred for 20 hours. The solvent wasdistilled off under reduced pressure The residue using n-hexane: ethyl acetatewith a volume ratio of 10: 1 eluent tocarry out column chromatography, graduallyincreasing the polarity to hexane: ethyl acetate with a volume ratio of 5: 1 togive a product of 9.6g (3.1X102 mole) a bromo group substituted by Phthalimide.The product with 8g (6. 3X 10 2 mol) of sodium sulfite, 160ml waterand 100ml95% ethanol mixed reaction was heated to 100 C for 20h, theremaining solvent was drained, and the resulting residue was mixed with 98ml ofconcentrated hydrochloric acid then was heated to 110 C the for 20H, it was drained,with water – 95% ethanol on the residue to carry out recrystallization to give 3.9g of 6-amino-1-hexylsulfonic acid (totalyield 50%).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1074-82-4.

Reference:
Patent; Institute of Chemistry Chinese Academy of Sciences; zhao, jingquan; DENG, HONG; XEI, JIE; (16 pag.)CN101948412; (2016); B;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem