1074-82-4 Archives - Page 2 of 9 - Indolines-derivatives

Sources of common compounds: 1074-82-4

Reference of 1074-82-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1074-82-4, name is Potassium 1,3-dioxoisoindolin-2-ide, This compound has unique chemical properties. The synthetic route is as follows.

(Synthesis of Intermediate 1)96.2 g (1.04 mol) of chloroacetone was added to 300 ml of N-methylpyrrolidone (NMP), and the mixture was stirred at 15 to 20 C. 175 g (0.945 mol) of phthalimide potassium was added in portions to the solution, while the temperature of reaction solution was kept at 30 C. or lower. After addition, the mixture was stirred at room temperature for two hours, to complete the reaction. After reaction, the reaction solution was poured into 3,000 ml of water, allowing precipitation of the crystal. The crystal was filtered, washed with water and dried, to give 163 g of an intermediate 1 (yield: 84.9%).

The chemical industry reduces the impact on the environment during synthesis Potassium 1,3-dioxoisoindolin-2-ide. I believe this compound will play a more active role in future production and life.

Reference:
Patent; FUJIFILM CORPORATION; US2012/238752; (2012); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Continuously updated synthesis method about 1074-82-4

Related Products of 1074-82-4, A common heterocyclic compound, 1074-82-4, name is Potassium 1,3-dioxoisoindolin-2-ide, molecular formula is C8H4KNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A 500 mL round-bottom flask was charged with4.63 g (0.025 mol) Phthalimide potassium salt, dissolve in 120 mL Anhydrousacetone. 6.9 g (0.05 mol) potassium carbonate and 11.75 g (0.0625 mol) 1,2-Dibromoethanewas added. The solution was heated to reflux for 8 h. The stirring mixture wasallowed to cool, and then was filtered. The solids were washed with 50 mL ofacetone, followed by 50 mL of EtOAc. The filtrate and the washer liquid werepooled and concentrated in a rotary evaporator, then purified by flashchromatography on SiO2 (gradient, 1:6 to 1:4 petroleum ether:EtOAc)to obtain 5.2 g (81.8%) of N-(2-Bromoethyl) phthalimideas a white solid.

The synthetic route of 1074-82-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Si, Weijie; Zhang, Tao; Zhang, Lanxiang; Mei, Xiangdong; Dong, Mengya; Zhang, Kaixin; Ning, Jun; Bioorganic and Medicinal Chemistry Letters; vol. 26; 9; (2016); p. 2380 – 2382;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Some scientific research about 1074-82-4

Application of 1074-82-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1074-82-4, name is Potassium 1,3-dioxoisoindolin-2-ide belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Into a reaction vessel were put potassium phthalimide (5.00g, 27.0mmol), benzyltrimethylammonium chloride (0.50g, 2.70mmol) and DMF (50ml) and then thereto was added (R)-epichlorohydrin (5.00g, 54.0mmol). The mixture was stirred at room temperature for 16 hours and the solvent was removed. To the residue was added ethyl acetate (30ml), the mixture was washed with water (20ml) and ethyl acetate was removed to give crude (R)-glycidylphthalimide (4.48g, yield: 82%, optical purity: 63%e.e.) as a white solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Potassium 1,3-dioxoisoindolin-2-ide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; DAISO CO., LTD.; EP1403267; (2004); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Share a compound : C8H4KNO2

Synthetic Route of 1074-82-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1074-82-4 as follows.

Into a reaction vessel were put potassium phthalimide (5.00g, 27.0mmol), benzyltrimethylammonium chloride (0.50g, 2.70mmol) and tert -buyl alcohol (50ml) and then thereto was added (S)-epichlorohydrin (6.53g, 54.0mmol). The mixture was stirred at 20C for 24 hours and the solvent was removed. To the residue was added ethyl acetate (30ml), the mixture was washed with water (20ml), and then ethyl acetate was removed to give crude (S)-glycidylphthalimide (3.95g, yield: 72%, optical purity: 97%e.e.) as a white solid.

According to the analysis of related databases, 1074-82-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; DAISO CO., LTD.; EP1403267; (2004); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Share a compound : 1074-82-4

Synthetic Route of 1074-82-4, The chemical industry reduces the impact on the environment during synthesis 1074-82-4, name is Potassium 1,3-dioxoisoindolin-2-ide, I believe this compound will play a more active role in future production and life.

[0714] Step 11: Synthesis of 2-(5-bromopentyl) isoindoline-1,3-dione (14-k) To a stirred solution of 1,5-dibromopentane (13-k) (170.58 mL, 1.26 mol) in DMF (1.5 L) was added potassium phthalate (12-k) (78.0 g, 0.42 mol) portion-wise over 30 min at room temperature. After complete addition, the reaction mixture was stirred at 90C for 18 h, then quenched with water (3 L) and extracted with diethyl ether (500 mL x 4). The combined organic extracts were washed with water (500 mL x 2), followed by brine (500 mL x 2) and dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to obtain the crude. The residue was purified by silica gel column chromatography (60-120 mesh) using 5-10% EtOAc / hexanes to afford 14-k as an off-white solid (81 g, 65% yield). 1H NMR (400 MHz, CDCl3): delta 7.82 (dd, J = 5.5, 3.1Hz, 2H), 7.69 (dd, J = 5.5, 3.0 Hz, 2H), 3.68 (t, J = 7.2 Hz, 2H), 3.38 (t, J = 6.8 Hz, 2H), 1.93-1.85 (m, 2H), 1.70 (p, J = 7.5 Hz, 2H), 1.53-1.43 (m, 2H).

Reference:
Patent; CV6 THERAPEUTICS (NI) LIMITED; LADNER, Robert D.; (345 pag.)WO2018/128720; (2018); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

The important role of 1074-82-4

Synthetic Route of 1074-82-4, These common heterocyclic compound, 1074-82-4, name is Potassium 1,3-dioxoisoindolin-2-ide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of potassium 1,3-dioxoisoindolin-2-ide (1.85 g, 10.0 mmol), potassium iodide (0.08 g, 0.5 mmol) in acetone (25.0 mL), 1,2-dibromoethane dissolved in acetone (5.0 mL) was added by dropping funnel (3.72 g, 20.0 mmol), refluxed for 10 h. Monitored by TLC, and then filtered, concentrated by vacuum. The crude compound was purified by column chromatography on silica gel to give the desired intermediate 4 2-(2-bromoethyl) isoindoline-1,3-dione (1.83 g, 72.5% yield) as a white solid.

Statistics shows that Potassium 1,3-dioxoisoindolin-2-ide is playing an increasingly important role. we look forward to future research findings about 1074-82-4.

Reference:
Article; Xie, Ruliang; Mei, Xiangdong; Ning, Jun; Chemical and Pharmaceutical Bulletin; vol. 67; 4; (2019); p. 345 – 350;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

The origin of a common compound about 1074-82-4

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1074-82-4, name is Potassium 1,3-dioxoisoindolin-2-ide, A new synthetic method of this compound is introduced below., Formula: C8H4KNO2

Potassium phthalimide (0.93 g; 5.00 mmol), methyl iodide (0.74 g, 5.20 mmol) and DMF (5 mL) were heated at reflux for 1h. The mixture was then poured into water (30 mL) and extracted with dichloromethane (3 × 10 mL). After evaporation of the solvent, the crude product was recrystalized from ethanol.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Zagorski, Piotr M.; Jo?wiak, Andrzej; P?otka, Mieczys?aw W.; Cal, Dariusz; Tetrahedron Letters; vol. 57; 17; (2016); p. 1835 – 1837;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Brief introduction of C8H4KNO2

Electric Literature of 1074-82-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1074-82-4 as follows.

To a solution of 1 -bromo-4-bromomethyl-benzene (3.0 g, 12.0 mmol, 1.0 eq) in DMF (40 mL) was added phthalimide potassium (4.4 g, 24.0 mmol, 2.0 eq). The reaction mixture was stirred for 1 h at rt Water was added, and the mixture was extracted with EtOAc. The organic layer was dried over Na2S04 and evaporated to give 2-(4-bromo-benzyl)-isoindole-l,3-dione which was used as a white solid (4.0 g, quant)without further purification.