Category: 106976-23-2

Introduction of a new synthetic route about 106976-23-2

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 106976-23-2, name is 5-Bromo-6-methylindoline-2,3-dione, A new synthetic method of this compound is introduced below., Recommanded Product: 106976-23-2

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 106976-23-2, name is 5-Bromo-6-methylindoline-2,3-dione, A new synthetic method of this compound is introduced below., Recommanded Product: 106976-23-2

A 30% hydrogen peroxide sol. (2 mL/g) was added to a sol. of isatin derivative in 10 M of sodium hydroxide sol. (10 mL/g) at 70 C. and the reaction mixture was then held at this temperature for 1 h. The mixture was then cooled to 0 C., adjusted to pH 8 with conc. HCl, diluted with EE and then brought to pH 4-5. The organic phase was washed with water, dried (NaSO4) and the solvent removed. (Yield approx. 60%)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Gruenenthal GmbH; US2009/69320; (2009); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Application of 106976-23-2

Statistics shows that 5-Bromo-6-methylindoline-2,3-dione is playing an increasingly important role. we look forward to future research findings about 106976-23-2.

Electric Literature of 106976-23-2, These common heterocyclic compound, 106976-23-2, name is 5-Bromo-6-methylindoline-2,3-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 5-bromo-6-methyl-indoline-2,3-dione (980 mg, 4.08 mmol) in tetrahydrofuran (50 mL) at 0 C. was added NaBH4 (124 mg, 3.26 mmol). The mixture was stirred at 0 C. for 10 min. H2O (50 mL) was added and the mixture extracted with EtOAc (3*200 mL). The combined extracts were washed with brine (100 mL), dried with Na2SO4, filtered and concentrated to give crude 5-bromo-3-hydroxy-6-methyl-indolin-2-one (650 mg, 2.5 mmol, 61% yield) as a brown solid. LCMS (ESI) [M+Na]+=265.9.

Statistics shows that 5-Bromo-6-methylindoline-2,3-dione is playing an increasingly important role. we look forward to future research findings about 106976-23-2.

Reference:
Patent; Genentech, Inc.; Chan, Bryan; Daniels, Blake; Drobnick, Joy; Gazzard, Lewis; Heffron, Timothy; Huestis, Malcolm; Liang, Jun; Malhotra, Sushant; Mendonca, Rohan; Rajapaksa, Naomi; Siu, Michael; Stivala, Craig; Tellis, John; Wang, Weiru; Wei, BinQing; Zhou, Aihe; Cartwright, Matthew W.; Gancia, Emanuela; Jones, Graham; Lainchbury, Michael; Madin, Andrew; Seward, Eileen; Favor, David; Fong, Kin Chiu; Good, Andrew; Hu, Yonghan; Hu, Baihua; Lu, Aijun; US2018/282328; (2018); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem