Category: 1029691-06-2

Some common heterocyclic compound, 1029691-06-2, name is 2-(3-Oxocyclopentyl)isoindoline-1,3-dione, molecular formula is C13H11NO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C13H11NO3

Reference Synthesis Example 221 (0990) 3-(1,3-Dioxoisoindolin-2-yl)cyclopenta-1-en-1-yl trifluoromethanesulfonate (0991) To a dichloromethane solution (30 mL) of 2-(3-oxocyclopentyl)isoindoline-1,3-dione (1.08 g, 4.71 mmol), trifluoromethanesulfonic acid anhydride (1.16 mL, 7.06 mmol) and N,N-diisopropylethylamine (1.16 mL, 9.42 mmol) were added at 0 C. and the resultant mixture was stirred at 0 C. for 1 day. After completion of the reaction, the reaction solution was concentrated under reduced pressure and the obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate=2/1) to obtain the title compound (780 mg, yield 46%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1029691-06-2, its application will become more common.

Reference:
Patent; NISSAN CHEMICAL INDUSTRIES, LTD.; Saito, Noriko; Egi, Jun; Nagai, Hiroshi; Ueno, Megumi; Shintani, Yusuke; Inaba, Yusuke; Adachi, Michiaki; Hirai, Yuichi; Kawazu, Takeshi; Yasutake, Koichi; Takahashi, Daiki; (220 pag.)US9403798; (2016); B2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Reference of 1029691-06-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1029691-06-2, name is 2-(3-Oxocyclopentyl)isoindoline-1,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Preparation 2; (i?,5′)-2-(7-Bromo-l,2,3,4-tetrahydro-cyclopenta[b]indol-2-yl)-isoindole-l,3-dione; In a 5 L flask is mixed (i?,5′)-2-(3-oxo-cyclopentyl)-isoindole-l,3-dione (295.3 g, 1.29 mol), 4-bromophenyl hydrazine-HCl (287.9 g, 1.29 mol) and glacial acetic acid (3 L) with mechanical stirring. The reaction is refluxed for 5 h, and then cooled to room temperature. The reaction is poured into water (4 L) with rapid stirring. The solid is collected by vacuum filtration, washed with water (4 L) and air-dried for 30 min. The solid is slurried with MeOH (700 mL), collected by vacuum filtration and rinsed with MeOH (100 mL). The gray solid is air dried for 2 h, then dried overnight in a 50 0C vacuum oven to obtain 414.67 g (84%) of the title compound as a dark solid. ES/MS m/z (7W1Br) 381/383 [M+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(3-Oxocyclopentyl)isoindoline-1,3-dione, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ELI LILLY AND COMPANY; WO2009/140448; (2009); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

1029691-06-2, name is 2-(3-Oxocyclopentyl)isoindoline-1,3-dione, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 2-(3-Oxocyclopentyl)isoindoline-1,3-dione

Mix (+/-)-2-(3-oxo-cyclopentyl)-isoindole-1,3-dione (12.7 g, 55.3 mmol) and 4-cyanophenylhydrazine-HCl (8.53 g, 50.3 mmol) in HOAc (200 mL) and 4N HCl dioxane (50 mL). Using mechanical stirring, heat the reaction to 90 C. for 18 h, then add additional 4N HCl dioxane (20 mL). Heat the reaction to 100 C. for 18 h. Dilute the reaction mixture with water (600 mL) and collect a black solid by vacuum filtration. Sonicate the solid with MeOH (200 mL), then collect and dry in a vacuum oven to give 10.94 g (66%) of a gray-brown solid. MS (m/z): 328 (M+1), 326 (M-1).

The synthetic route of 1029691-06-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Gavardinas, Konstantinos; Green, Jonathan Edward; Jadhav, Prabhakar Kondaji; Matthews, Donald Paul; US2010/69404; (2010); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem