100510-65-4 Archives - Indolines-derivatives

28-Sep-2021 News Latest chemical Data For 100510-65-4

In chemical reaction engineering, simulations are useful for investigating and optimizing a particular reaction process or system., Reference of 100510-65-4

EXAMPLE G N-Propyl-N’-[2,3-dihydro-3,3-dimethyl-2-oxo-(1H)-indol-6-yl]-urea 3.52 g. (0.02 mole) 6-amino-2,3-dihydro-3,3-dimethyl-(1H)-indolin-2-one are suspended in 40 ml. anhydrous dioxan and mixed at ambient temperature within the course of 10 minutes with a solution of 1.7 g. (0.02 mole) n-propyl isocyanate in 10 ml. dioxan, whereupon a clear solution is formed. Shortly thereafter, the product begins to separate out as a crystalline mass. After 1 hour, the suspension is mixed with ligroin and the precipitate is filtered off with suction, washed with ligroin and diethyl ether and recrystallized from ethanol. Yield 3.91 g. (75% of theory); m.p. 223-225 C.

You can get involved in discussing the latest developments in this exciting area about 6-Amino-3,3-dimethylindolin-2-one.

Reference:
Patent; Boehringer Mannheim GmbH; US4985448; (1991); A;,
Indoline – Wikipedia,
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S-21 News What I Wish Everyone Knew About 100510-65-4

Recommanded Product: 6-Amino-3,3-dimethylindolin-2-one,The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research.

Example No.11: 6-(4-(Cyclopropylamino)furo[3,2-i/|pyrimidin-2-ylamino)-3,3- dimethylindolin-2-oneTo a flask was added 2-chloro-A^-cyclopropylfuro[3,2-i/]pyrimidin-4-amine (0.45 g, 2.14 mmol, Example No.3, Step C), 6-amino-3,3-dimethylindolin-2-one (0.378 g, 2.14 mmol, Astatech), K2C03 (0.89 g, 6.44 mmol) and i-AmOH (5 mL). To the mixture was added Pd2dba3 (0.1 18 g, 0.129 mmol) and X-Phos (0.123 g, 0.258 mmol). The mixture was heated to about 100 C and stirred for about 15 h. The mixture was filtered and the filtrate was directly purified by column chromatography eluting with 0 to 70% of 10% MeOH/DCM (containing 2M 1.5% NH3 in EtOH) and DCM (25 g silica gel)). The material was then dried in a vacuum oven at about 65 C for about 48 h. The solid was then suspended in Et20 (5 mL), sonicated for 2 min and filtered. The solid was dried in a vacuum oven at about 80 C for about 16 h to give 6-(4- (cyclopropylamino)furo[3,2-ii|pyrimidin-2-ylamino)-3,3-dimethylindolin-2-one (0.195 g, 26%o): LC/MS (Table 2, Method c) R, = 1.81 min.; MS m/z: 350 (M+H)+. Syk IC50 = A

You can get involved in discussing the latest developments in this exciting area about 6-Amino-3,3-dimethylindolin-2-one.

Reference:
Patent; ABBOTT LABORATORIES; CALDERWOOD, David, J.; WILSON, Noel, S.; COX, Philip; HOEMANN, Michael, Z.; CLAPHAM, Bruce; MULLEN, Kelly, D.; VASUDEVAN, Anil; VILLAMIL, Clara I; LI, Bin; SOMAL, Gagandeep; WO2012/48222; (2012); A1;,
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23-Sep News The origin of a common compound about 100510-65-4

Related Products of 100510-65-4, Chemical engineers ensure the efficiency and safety of chemical processes, adapt the chemical make-up of products to meet environmental or economic needs, and apply new technologies to improve existing processes.

EXAMPLE H Hexyl N-[2,3-dihydro-3,3-dimethyl-2-oxo-(1H)-indol-6-yl]-carbamate 5.27 g. (0.032 mole) Hexyl chloroformate are added dropwise, while cooling with ice and within the course of 15 minutes, to a suspension of 5.28 g. (0.03 mole) 6-amino-2,3-dihydro-3,3-dimethyl-(1H)-indolin-2-one and 4.6 ml. triethylamine in 50 ml. anhydrous dichloromethane. The solution is then stirred for 3 hours at ambient temperature, the solvent is removed in a vacuum and the residue is purified by flash column chromatography with heptane/butan-2-one (2:1 v/v) as elution agent. Yield 5.2 g. (60% of theory); m.p. 180-183 C. after recrystallisation from ethyl acetate.

Statistics shows that 6-Amino-3,3-dimethylindolin-2-one is playing an increasingly important role. we look forward to future research findings about 100510-65-4.

Reference:
Patent; Boehringer Mannheim GmbH; US4985448; (1991); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

New downstream synthetic route of C10H12N2O

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 100510-65-4, name is 6-Amino-3,3-dimethylindolin-2-one belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. Safety of 6-Amino-3,3-dimethylindolin-2-one

B. 6-(6-(3-chloropyridin-2-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-ylamino)-3,3-dimethylindolin-2-one A mixture of 6-amino-3,3-dimethylindolin-2-one (156 mg), 4-chloro-6-(3-chloropyridin-2-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine (100 mg), and CH3CN (5 mL) was run in a Microwave Reactor at 180 C. for 1 h. After cooling, the mixture was treated with sat. aq. Na2CO3 and extracted with EtOAc (30 mL*3). The combined organic layers were washed with brine, dried (Na2SO4) and concentrated. The residue was purified by column to give an off-white solid (120 mg, 80%). 1H NMR (d6-DMSO): 10.32 (s, 1H), 8.54 (s, 1H), 8.40 (s, 1H), 8.28 (dd, 1H, J=5.2, 1.6 Hz), 7.89 (dd, 1H, J=8.0, 1.6 Hz), 7.30 (s, 1H), 7.19 (s, 2H), 7.08 (dd, 1H, J=8.0, 4.8 Hz), 4.38 (s, 2H), 3.61 (t, 2H, J=6.0 Hz), 2.88 (t, 2H, J=5.6 Hz), 1.24 (s, 6H).

The synthetic route of 100510-65-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Kelly, Michael G.; Kincaid, John; Kaub, Carl J.; US2006/258689; (2006); A1;,
Indoline – Wikipedia,
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Analyzing the synthesis route of 100510-65-4

Related Products of 100510-65-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 100510-65-4, name is 6-Amino-3,3-dimethylindolin-2-one belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.

a) 25 g. (0.142 mol) 6-Amino-1,3-dihydro-3,3-dimethyl-(2H)-indolin-2-one in 250 ml. 2N hydrochloric acid were mixed, while cooling with ice, within the course of 15 minutes with a solution of 10.3 g. (0.15 mol) sodium nitrite in 20 ml. water and, after the addition, stirred for 15 minutes. After mixing with 2.13 g. (0.036 mol) urea, the clear solution, after stirring for a further 10 minutes, was added dropwise to a solution, warmed to 50 C., of 24.4 g. (0.5 mol) sodium cyanide, 15.2 g. (0.17 mol) cuprous cyanide and 22.6 g. (0.21 mol) sodium carbonate in 820 ml. water and heated for 5 minutes to 90 C. After cooling, the precipitate was filtered off with suction, washed with water and, after drying, recrystallized from ethanol. There were obtained 15 g. (57% of theory) 2,3-dihydro-3,3-dimethyl-2-oxo-(1H)-indole-6-carbonitrile in the form of colourless crystals; m.p. 243-246 C.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 6-Amino-3,3-dimethylindolin-2-one, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Boehringer Mannheim GmbH; US5019587; (1991); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Sources of common compounds: 100510-65-4

Related Products of 100510-65-4,Some common heterocyclic compound, 100510-65-4, name is 6-Amino-3,3-dimethylindolin-2-one, molecular formula is C10H12N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE A 6-Benzoylamino-2,3-dihydro-3,3-dimethyl-(1H)-indolin-2-one To a suspension of 5.28 g. (0.03 mole) 6-amino2,3-dihydro-3,3-dimethyl-(1H)-indolin-2-one and 4.6 ml. triethylamine in 50 ml. anhydrous dichloromethane is added dropwise at 0 C., within the course of 15 minutes, 4.36 g. (0.031 mole) benzoyl chloride, followed by stirring for 1 hour at ambient temperature. The reaction mixture is then mixed with 200 ml. ice water and the precipitate is filtered off with suction, washed with water and recrystallized from methanol. Yield 7.8 g. (93% of theory); m.p. 251-254 C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6-Amino-3,3-dimethylindolin-2-one, its application will become more common.

Reference:
Patent; Boehringer Mannheim GmbH; US4985448; (1991); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Sources of common compounds: 100510-65-4

Reference:
Patent; Boehringer Mannheim GmbH; US4985448; (1991); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Some tips on 100510-65-4

Step B: 6-(4-(2,2-Difluoroethylamino)furo[3,2-i/|pyrimidin-2-ylamino)-3,3-dimethylindolin- -oneTo a vial was added Pd2dba3 (0.235 g, 0.257 mmol), Cs2C03 (2.37 g, 7.28 mmol) and Ru-Phos (0.240 g, 0.514 mmol) in i-AmOH (8.00 mL). The mixture was evacuated and purged with N2. The mixture was stirred at about 65 C for about 20 min. 2-Chloro-A^-(2,2-difluoroethyl)furo[3,2- i/]pyrimidin-4-amine (1.00 g, 4.28 mmol) and 6-amino-3,3-dimethylindolin-2-one (0.754 g, 4.28 mmol, Astatech) were added in one portion. Additional i-AmOH (12.00 mL) was added. The mixture was evacauted and purged with N2. The mixture was stirred at about 70 C for about 5 h, stirred at about 60 C for about 15 h and then stirred at about 75 C for about 2 h. The mixture was cooled to rt and filtered. The precipitate was washed with DCM (20 mL) and MeOH (20 mL). The combined filtrate was concentrated and purified by column chromatography eluting with 25-65% EtOAc/heptane (40 g silica gel) to give a crude material. The material was suspended in Et20 (about 15 mL) and sonicated. The suspension was filtered and washed with Et20 (50 mL), then with DCM (about 30 mL). The precipitate was dissolved in DCM (50 mL), combined with filtrate, concentrated under reduced pressure, dissolved in MeOH (40 mL), and adsorbed onto silica gel (MeshNo. 200-400, 60A; 3 g). The material was purified by column chromatography eluting with 0 to 28% of 10% MeOH/DCM and DCM (40 g silica gel) to give a solid. The solid was purified by mass-triggered HPLC (Table 2, Method x) purification to give 6- (4-(2,2-difluoroethylamino)furo[3,2-i/]pyrimidin-2-ylamino)-3,3-dimethylindolin-2-one(0.397 g, 25%): LC/MS (Table 2, Method c) R, = 1.75 min.; MS m/z: 374 (M+H)+. Syk IC

The synthetic route of 100510-65-4 has been constantly updated, and we look forward to future research findings.

Brief introduction of C10H12N2O

C. 6-(7-(3-Chloropyridin-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-ylamino)-3,3-dimethylindolin-2-one A mixture of the 4-chloro-7-(3-chloropyridin-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine (50 mg, 0.18 mmol), 6-amino-3,3-dimethylindolin-2-one (63 mg, 0.36 mmol), and acetonitrile (3 mL) was heated in a sealed tube via at 180 C. for 60 min. The mixture was treated with EtOAc (50 mL) and sat. aq. solution of NaHCO3. The organic layer was separated and washed with brine, dried (Na2SO4), and evaporated. The residue was purified by flash chromatography over silica gel to give a light yellow solid (50 mg). MS: M+H=421.6 & 423.5 (M+1) 1H NMR (DMSO-d6) delta 10.33 (s, 1H), 8.44 (s, 1H), 8.41 (s, 1H), 8.24 (dd, J=4.8, 1.6 Hz, 1H), 7.86 (dd, J=8.0, 1.6 Hz, 1H), 7.38 (d, J=1.6 Hz, 1H), 7.24-7.18 (m, 2H), 7.03 (dd, J=8.0, 4.8 Hz, 1H), 4.35 (s, 2H), 3.67 (t, J=5.6 Hz, 2H), 2.81 (t, J=5.6 Hz, 2H), 1.24 (s, 6H).

Reference:
Patent; Kelly, Michael G.; Janagani, Satyanarayana; Wu, Guoxian; Kincaid, John; Lonergan, David; Fang, YunFeng; Wei, Zhi-Liang; US2005/277643; (2005); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

The origin of a common compound about C10H12N2O

Related Products of 100510-65-4, A common heterocyclic compound, 100510-65-4, name is 6-Amino-3,3-dimethylindolin-2-one, molecular formula is C10H12N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of compound 8 (100 mL, compound 7, 23.7 mmol from 5.3 g) at 0 to 5 degrees, a methylene chloride solution of compound 23 (4.0 g, 18.8 mmol) and triethylamine (2.6 mL, 18.8 mmol) was added dropwise. The reaction solution was stirred at room temperature overnight, washed with aqueous sodium bicarbonate solution, washed with water, the organic phase was concentrated under reduced pressure, filtered, and the filter cake was washed with a small amount of dichloromethane, and dried in vacuo to give an off-white solid compound 24 (5.2 g, yield 65.7%).

The synthetic route of 100510-65-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Suzhou Ruiming Drug Discovery Co., Ltd.; Zhang Fei; Feng Zixia; (33 pag.)CN110950868; (2020); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem