A common heterocyclic compound, 446292-07-5, name is (R)-2-(2-Hydroxy-3-((4-(3-oxomorpholino)phenyl)amino)propyl)isoindoline-1,3-dione, molecular formula is C21H21N3O5, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 446292-07-5.
Amino alcohol 170 gm, 0.4293 moles and Triethylamine 41 14.72 gms, 0.9459 moles, was charged to Dichloromethane 2380 ml and cooled reaction mass to 0C – 5C. To the cooled reaction mass added triphosgene solution, 51.09 gms in 340 ml MDC, 0.18 moles drop wise at 5C – 10C in 60 min, and stirred for 60 – 90 min. Reaction mass quenched with water and distilled out MDC layer atmospherically till thick solid mass obtained. To the thick solid, charged tetrahydrofuran 1360 ml, distilled out 130 ml under vacuum. Cooled slurred mass to 25C -30C, stirred for 30 min, filtered. Wet material dried at 55C -60C to afford 162 gm dry material. Yield- 89%
The synthetic route of (R)-2-(2-Hydroxy-3-((4-(3-oxomorpholino)phenyl)amino)propyl)isoindoline-1,3-dione has been constantly updated, and we look forward to future research findings.
Reference:
Patent; UNICHEM LABORATORIES LTD; SATHE, Dhananjay G.; DAS, Arijit; RAIKAR, Sanjay; SURVE, Yashwant S.; PANDIT, Bhushan S.; (25 pag.)WO2018/127762; (2018); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem