Some common heterocyclic compound, 3485-84-5, name is N-Vinylphthalimide, molecular formula is C10H7NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of N-Vinylphthalimide
Step 2: Preparation of 4-{3-[(E)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)vinyl]-phenoxy}-N-methylpyridine-2-carboxamide To a degassed solution of solution 4-(3-iodophenoxy)-N-methylpyridine-2-carboxamide (11.4 g, 32.4 mmol) in anhydrous DMF (100 mL) was added palladium acetate (0.15 g, 0.65 mmol), tri-o-tolylphosphine (0.79 g, 2.58 mmol), 2-vinyl-1H-isoindole-1,3(2H)-dione (5.60 g, 32.4 mmol), and DIPEA (11.5 mL 64.5 mmol). After degassing the mixture again, the reaction was heated at 90 C. overnight under nitrogen. The reaction mixture was then cooled to rt and concentrated. The mixture was diluted with water and extracted with DCM (2*). The organic solutions were combined and washed with brine, dried over Na2SO4, filtered, and concentrated. The residue was purified by column chromatography to give 4-{3-[(E)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)vinyl]-phenoxy)-N-methylpyridine-2-carboxamide (8.9 g, 69%) as a yellow solid. 1H NMR (300 MHz, CDCl3) delta: 8.40 (d, 1H), 7.96-8.05 (m, 1H), 7.89-7.94 (m, 2H), 7.73-7.80 (m, 3H), 7.65 (d, 1H), 7.33-7.44 (m, 3H), 7.20 (t, 1H), 6.96-7.01 (m, 2H), and 3.01 (d, 3H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3485-84-5, its application will become more common.
Reference:
Patent; Millennium Pharmaceuticals, Inc.; US2008/64729; (2008); A1;,
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