Adding a certain compound to certain chemical reactions, such as: 7223-50-9, name is N-Propargylphthalimide, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7223-50-9, SDS of cas: 7223-50-9
General procedure: To a solution of alkyne (1.0 mmol) in PEG-400/H2O(4:1) was added [Ru(p-cymene)Cl2]2 (0.01 mmol), and themixture stirred at room temperature. Upon completion of thereaction (monitoring by TLC), the reaction mixture was dilutedwith Et2O (10 mL), stirred for 10 min, and allowed to stand in anice-salt bath to solidify the PEG-400. The organic layer wasdecanted, dried over anhydrous Na2SO4, filtered, and concentratedunder reduced pressure. The residue obtained was purifiedby silica gel flash column chromatography (ethyl acetate-petroleum ether) to give the pure product.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, N-Propargylphthalimide, and friends who are interested can also refer to it.
Reference:
Article; Mainkar, Prathama S.; Chippala, Venkataraju; Chegondi, Rambabu; Chandrasekhar, Srivari; Synlett; vol. 27; 13; (2016); p. 1969 – 1972;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem