Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 32692-19-6, name is 5-Nitroindoline, A new synthetic method of this compound is introduced below., COA of Formula: C8H8N2O2
REFERENCE EXAMPLE 6; 5-Amino-1-isopropy.sulfonylindofine; a) 1-isopropy.sulfonyf~5-?itroindoline; 1 mL of TEA (7.61 mmol) and isopropylsulfonyl chloride (0.5 mL, 4.57 mmoi) were added at 0 0C to a solution of 5-nitroindoline (0.5 g, 3.05 mmol) in CH 2Cl2 (50 mL). The reaction mixture was stirred at room temperature for 48 h and then at reflux temperature for 18 h. The crude product obtained was diluted with a saturated aqueous solution of NaHCOs and extracted thrice with CH2Cl2. The combined organic phases were separated, dried over Na2SO4 and the solvent was evaporated to dryness. The desired compound was obtained in quantitative yield and used in next step without further purification.
The synthetic route of 32692-19-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PALAU PHARMA, S.A.; SALAS SOLANA, Jorge; ALMANSA ROSALES, Carmen; SOLIVA SOLIVA, Robert; FONTES USTRELL, Montserrat; COMELLES ESPUGA, Josep; WO2010/34740; (2010); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem