Adding a certain compound to certain chemical reactions, such as: 4702-13-0, name is N-Phthaloylglycine, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4702-13-0, Product Details of 4702-13-0
Typical Procedure: To a 30-mL vial was added N-phthaloylglycine (2.05 g, 10 mmol) and SOCl2 (8 mL) and the vial was sealed. The reaction was stirred in an oil bath at 60 C for 8 h. The mixture was cooled to r.t., the SOCl2 was removed in vacuo, hexane (10 mL) was added, and the mixture was stirred for 10 min resulting in white solid. After filtration, the solid (2.0 g, 90%) was washed with hexane and used directly in the next reaction. Phthaloylglycyl chloride (2.0 g, 9.0 mmol) in CH2Cl2 (8 mL) was added dropwise to the solution of 11a (2.2 g, 7.9 mmol) and Et3N (3.0 mL) in CH2Cl2 (50 mL). The mixture was stirred at r.t. until completion of the reaction, then diluted with CH2Cl2 (150 mL). The organic phase was washed with H2O (3 ¡Á 40mL) and brine, dried (anhyd Na2SO4), and concentrated in vacuo. The residue was purified by flash column chromatography (silicagel) to afford 10a (3.2 g, 89%) as a yellowish solid.
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Reference:
Article; Huang, Liye; Yu, Ruina; Leng, Ling; Gong, Feng; Zhu, Xinhai; Wan, Yiqian; Synthesis; vol. 46; 17; (2014); p. 2317 – 2326;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem