Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2058-72-2, name is 5-Bromo-1-methylindoline-2,3-dione, A new synthetic method of this compound is introduced below., SDS of cas: 2058-72-2
General procedure: A solution of isatins 1 (0.3 mmol), 4-methylpent-3-en-2-one 2 (0.4 mmol), 10 mol% of Et2NH in 3.0 mL of MeOH at 25 C for 24 h. Then, tartaric acid (40 eq) and HCl (6 N, 10 muL) were added at reflux for 12 h. After the completion of reaction, as indicated by TLC, the removal of solvent and purification by flash column chromatography (hexane/EtOAc 8:1?6:1) were performed to furnish the corresponding products 3.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Zhou, Gen; Wei, Qi-Di; Wang, Guan-Lian; Gong, Yi; Liu, Huan-Huan; Liu, Xiong-Li; Chen, Lin; Zhou, Ying; Synthetic Communications; vol. 48; 9; (2018); p. 1033 – 1039;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem