In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 169037-23-4, name is 5-(Trifluoromethoxy)indoline-2,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. name: 5-(Trifluoromethoxy)indoline-2,3-dione
General procedure: A mixture of bisarylidenepiperidin-4-one (1.36 mmoL), isatin (2.72 mmoL) and L-phenylalanine (2.72 mmoL) were heated with stirring in [bmim]Br medium (3 mL) for 1 h at 100 C. After completion of the reaction (TLC), ethyl acetate (2 x 5 mL) was added and the reaction mixture was stirred for 10 min. The organic layer was removed under reduced pressure and the crude product was purified by column chromatography (ethyl acetate:hexane v/v 3:7). 5′-Benzyl-4′-(m-tolyl)-5-(trifluoromethoxy)spiro[3,2′]oxindolopyrrolidino-4′-(methylphenyl)-1?-styryl-5-benzylidene-spiro[3′.3?]piperidin-4?-one (5h): Melting point 234-236 C; white solid, 88%; 1H-NMR (CDCl3, 400 MHz): delta/ppm 4.99 (d, J = 14.5 Hz, 1H), 4.63-4.68 (m, 1H), 4.34 (d, J = 10.0 Hz, 1H), 3.77 (d, J = 14.00 Hz, 1H), 3.68 (d, J = 15.00 Hz, 1H), 3.38-3.47 (dd, J = 15 Hz, 1H), 3.00-3.03 (dd, J = 14.5 Hz,1H), 2.72-2.76 (m, 1H), 2.56 (d, J = 14.0 Hz, 1H), 2.33 (s, 3H), 2.27 (s, 3H), 6.60 (d, J = 14.5 Hz, 2H), 6.79-7.71 (m, 21H, Ar); 13C-NMR (CDCl3, 100 MHz): delta/ppm 21.1, 21.4, 39.4, 47.4, 52.8, 52.9, 61.1, 66.9, 70.8, 100.8, 109.5, 119.5, 120.9, 121.5, 122.4, 123.9, 124.3, 126.3, 128.4, 128.5, 128.6, 129.2, 129.4, 129.5, 130.5, 131.7, 133.6, 135.3, 136.2, 136.8, 138.3, 138.5, 138.8, 139.7, 139.8. 140.0, 144.3, 179.7, 197.1. EI-MS: m/z 739 (M+). Anal. Calcd for C46H40F3N3O3: C, 74.68; H, 5.45; N, 5.68. Found: C, 74.77; H, 5.55;N, 5.81.
The synthetic route of 169037-23-4 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Arumugam, Natarajan; Almansour, Abdulrahman I.; Kumar, Raju Suresh; Govindasami, Periyasami; Al-thamili, Dhaifallah M.; Krishnamoorthy, Rajapandian; Periasamy, Vaiyapuri Subbarayan; Alshatwi, Ali A.; Mahalingam; Thangamani, Shankar; Menendez, J. Carlos; Molecules; vol. 23; 5; (2018);,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem