Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 341988-36-1, name is Methyl indoline-6-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., name: Methyl indoline-6-carboxylate
To the solution of methyl ind line~6-carboxyiate (150 mg, 0,85 mmoi) in 5 ml acetone were added K2CO3 (351 mg, 2.54 mmoi) and 3-(triuQromethyl)benzenesuifonyi chloride (271 mu,, 1.69 mmoi). The reaction mixture was stirred at room temperature overnight. The completion of the reaction was monitored by HPLC Upon completion, the solvent was removed in vacuo. The crude product was purified by Combiflash silica gel chromatography (0-20percent of EtOAc in hexarse), which provided 277 mg (85percent) of the title compound as a colorless solid; 1H NMR (400 MHz, CDCis) 5 = 8.25 (d, J – 1.5 Hz, 1 H), 8.12 (s, 1 H), 8.00 (d, J – 8.1 Hz, 1 H), 7.84 (d, J = 7.9 Hz, 1 H), 7,74 (d.d, J =¡¤ 1.4, 7.8 Hz, 1 H), 7.66 – 7.58 (m, 1 H), 7.17 (d, J – 7.9 Hz, 1 H), 4.01 (t, J – 8.6 Hz, 2 H), 3.95 (s, 3 H), 3.00 (t, J ~ 8.6 Hz, 2 H).
According to the analysis of related databases, 341988-36-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; THE SCRIPPS RESEARCH INTITUTE; GRIFFIN, Patrick, R.; KAMENECKA, Theodore, M.; DOEBELIN, Christelle; CHANG, Mi, Ra; (109 pag.)WO2018/52903; (2018); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem