Synthetic Route of 5332-26-3,Some common heterocyclic compound, 5332-26-3, name is 2-(Bromomethyl)isoindoline-1,3-dione, molecular formula is C9H6BrNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
1.02 g (4.2 mmol) of N-(bromomethyl)phthalimide (1c), 1.09 g (8.0 mmol) of phenylacetic acid and 0.56 g (4.0 mmol) of potassium carbonate were mixed in 120 mL of a mixture of acetone and distilled water (1:1 vol %). The solution was heated for 5 h to approx. 70 C. After evaporation of acetone, the product precipitated as a colorless solid. Filtration, washing with water and drying gave 465 mg (1.6 mmol; 37%) of 6 as a colorless solid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(Bromomethyl)isoindoline-1,3-dione, its application will become more common.
Reference:
Article; Anamimoghadam, Ommid; Mumtaz, Saira; Nietsch, Anke; Saya, Gaetano; Motti, Cherie A.; Wang, Jun; Junk, Peter C.; Qureshi, Ashfaq Mahmood; Oelgemoeller, Michael; Beilstein Journal of Organic Chemistry; vol. 13; (2017); p. 2833 – 2841;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem