Adding a certain compound to certain chemical reactions, such as: 1677-48-1, name is 5,6-Dichloroindoline-2,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1677-48-1, Application In Synthesis of 5,6-Dichloroindoline-2,3-dione
Example 2 5,6-dichloro-1-methylisatin (2a). To a solution of 5,6-dichloroisatin (0,15 g; 0.7 mmol) in anhydrous DMF (5 ml) was added sodium hydride (40 mg, 60% dispersion in mineral oil). When the evolution of hydrogen had ceased iodomethane (0.1 ml) was added and the mixture was stirred for 20 min. at ambient temperature. Water (15 ml) and glacial acetic acid (0.1 ml) were added and the product was filtered off, washed with water and dried to yield 5,6-dichloro-1-methylisatin (0.13 g, 81%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5,6-Dichloroindoline-2,3-dione, and friends who are interested can also refer to it.
Reference:
Patent; Jensen, Bo Skaaning; Jorgensen, Tino Dyhring; Ahring, Philip K.; Christophersen, Palle; Strobaek, Dorte; Teuber, Lene; Olesen, Soren Peter; US2002/16354; (2002); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem