Electric Literature of 118289-55-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 118289-55-7, name is 6-Chloro-5-(2-chloroethyl)indolin-2-one belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
EXAMPLE 1; 5- (2- (4- (1, 2-benzisotliiazol-3-yl)-l-piperazitiyl) ethyl)-6-chloro-1, 3-diliydro-2H-indole-2-one (Ziprasidone); In a 10 liter three-necked round bottom flask sodium carbonate (742 g) and pure water (3.06 liter) is charged. To the above stirred solution 1, 2-benzisothiazole-3-piperazinyl HCl (611 g, 2 moles) is added at ambient temperature and stirred the reaction mixture additionally for 1 hour. To the obtained suspension 2-Chloroethyl-6-chloro oxindole (430 g, 2 moles) and sodium iodide (20 g) is added. The combined reaction mixture is heated at 60 to 90 C for 20 to 30 hours. After completion of the reaction, reaction mass is cooled to ambient temperature and the slurry thus obtained is stirred for 1 hour more and then filtered. The wet tan colored crude free base is suspended in water (7.50 liter), heated to 75 to 80 C under stirring for 1 hour and filtered at 45 to 50 C temperature. Wet compound is dried at 65 to 70 C for 10 to 12 hours to get desired product in 752 gm yield (HPLC Purity 95 to 96%).
The synthetic route of 6-Chloro-5-(2-chloroethyl)indolin-2-one has been constantly updated, and we look forward to future research findings.
Reference:
Patent; WOCKHARDT LIMITED; JAWEED MUKARRAM, Siddiqui, Mohammed; MERWADE, Aravind, Yekanathsa; SINGH, Kumar, Kamlesh, Laxmi; SOLANKI, Pawan, Vrajlal; WO2005/54235; (2005); A1;,
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