118289-55-7, name is 6-Chloro-5-(2-chloroethyl)indolin-2-one, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C10H9Cl2NO
2 moles of Piperazine Benzisothiazole , 1 mole of 5-(2-chloroethyl)-6- chlorooxindole in water (20 times based on benzisothiazole) and in the presence of dispersing agent. All the reactants are charged in to the flask and refluxed under nitrogen, -under stirring ^or^ r2-i6hr. After the completion “of the reaction,” the” reaction mass is cooled to room temperature and the resulting mass is filtered. It is slurried inwater and then in IPA and isolated by filtration. The solid is dried at 95- 1000C.Yield: 92%, Purity 99 %( min).
The synthetic route of 118289-55-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ALKEM LABORATORIES LTD.; WO2009/116085; (2009); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem