Electric Literature of 106976-23-2, These common heterocyclic compound, 106976-23-2, name is 5-Bromo-6-methylindoline-2,3-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 5-bromo-6-methyl-indoline-2,3-dione (980 mg, 4.08 mmol) in tetrahydrofuran (50 mL) at 0 C. was added NaBH4 (124 mg, 3.26 mmol). The mixture was stirred at 0 C. for 10 min. H2O (50 mL) was added and the mixture extracted with EtOAc (3*200 mL). The combined extracts were washed with brine (100 mL), dried with Na2SO4, filtered and concentrated to give crude 5-bromo-3-hydroxy-6-methyl-indolin-2-one (650 mg, 2.5 mmol, 61% yield) as a brown solid. LCMS (ESI) [M+Na]+=265.9.
Statistics shows that 5-Bromo-6-methylindoline-2,3-dione is playing an increasingly important role. we look forward to future research findings about 106976-23-2.
Reference:
Patent; Genentech, Inc.; Chan, Bryan; Daniels, Blake; Drobnick, Joy; Gazzard, Lewis; Heffron, Timothy; Huestis, Malcolm; Liang, Jun; Malhotra, Sushant; Mendonca, Rohan; Rajapaksa, Naomi; Siu, Michael; Stivala, Craig; Tellis, John; Wang, Weiru; Wei, BinQing; Zhou, Aihe; Cartwright, Matthew W.; Gancia, Emanuela; Jones, Graham; Lainchbury, Michael; Madin, Andrew; Seward, Eileen; Favor, David; Fong, Kin Chiu; Good, Andrew; Hu, Yonghan; Hu, Baihua; Lu, Aijun; US2018/282328; (2018); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem