Reference of 21857-45-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 21857-45-4 as follows.
To a solution of 5-methoxyindoline (180 mg, 1.21 mmol) in 3.6 mL of acetic acid was added 3,3-dimethylbutylaldehyde (0.18 mL, 1.4 mmol) and sodium cyanoborohydride (190 mg, 3.0 mmol) at room temperature, successively. After the reaction mixture was stirred for 2 h, the reaction mixture was basified by saturated NaHCO3 aqueous solution and the solution was extracted with ethyl acetate (20 mL). The extract was washed with brine, and dried over MgSO4. After filtration, the filtrate was concentrated in vacuo, and the residue was purified by silica gel column chromatography (hexane/ethyl acetate=95/5 to 90/10) to obtain 5-methoxy-1-(3,3-dimethylbutyl)indoline (74.6 mg, 26%).
According to the analysis of related databases, 21857-45-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; TOKYO INSTITUTE OF TECHNOLOGY; KYOTO UNIVERSITY; US2011/294850; (2011); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem