These common heterocyclic compound, 552330-86-6, name is 5-Bromoisoindolin-1-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 5-Bromoisoindolin-1-one
[0264] 5-Bromo-2,3-dihydro-isoindol-l-one (l.OOg, 4.72mmol), l-bromomethyl-4-methyl-benzene (1.14g, 6.14mmol) and cesium carbonate (3.08g, 9.44mmol) were suspended in anhydrous NMP (lOmL). The mixture was immersed in a 60C oil bath for 16.5 hours. The cooled reaction mixture was poured into water and extracted with ethyl acetate. The organic phase was washed with water and brine, dried over magnesium sulfate, filtered and concentrated. Column chromatography (20% to 40% ethyl acetate/hexanes) provided the title compound as a yellow solid (1.18g, 79%). 1H NMR CDC13: 7.76 (d, 1H), 7.62 (d, 1H), 7.55 (s, 1H), 4.76 (s, 2H), 4.24 (s, 2H), 2.35 (s, 3H).
The synthetic route of 5-Bromoisoindolin-1-one has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/20879; (2006); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem