Reference of 102359-00-2, A common heterocyclic compound, 102359-00-2, name is 2-Oxoindoline-5-carboxylic Acid, molecular formula is C9H7NO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
After standing overnight the filtrate yielded 2 g of 5-carboxy-2-oxindole as a yellow solid. The crude dark brown product was dissolved in hot methanol, the insoluble material removed by filtration and the filtrate concentrated to give 5.6 g of 5-carboxy-2-oxindole as a brown solid. The combined yield was 97%. 1H-NMR (360 MHz, DMSO-d6) delta 12.56 (s, br, 1 H, COOH-5), 10.70 (s, 1 H, NH-1), 7.82 (dd, J=1.57, 7.79 Hz, 1 H, H-6), 7.74 (s, br, 1 H, H-4), 6.87 (d, J=7.79 Hz, 1 H, H-7), and 3.53 (s, 2 H, CH2-3). MS m/z (relative intensity, %) 178 ([M+1]+, 100).
The synthetic route of 102359-00-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Sugen, Inc.; US6395734; (2002); B1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem