Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 25369-33-9, name is 7-Chloroindolin-2-one, This compound has unique chemical properties. The synthetic route is as follows., Formula: C8H6ClNO
To a cooled (0 C.) solution of 7-chioroindolin-2- one (1.0 g, 6.0 mmol) in TFA (11 mE) was added N-bromosuccinimide (1.0 g, 6.0 mmol) in portions. The reaction mixture was stirred at 0 C. for 6 h. The solvent was removed in vacuo and the residue was diluted with DCM (25 mE) and concentrated, followed by a similar sequence with EtOAc. The crude product was triturated with ethanol to provide the title compound as a white solid (861 mg, 58% yield). MS (ESI): mass calcd. for C8H5I3rC1NO, 244.9; mlz found, 246.0 [M+H]. ?H NMR (500 MHz, DMSO-d5) oe 10.92 (s, 1H), 7.52-7.48 (m, 1H), 7.38 (d, J=1.2 Hz, 1H),3.62 (s, 2H).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 25369-33-9.
Reference:
Patent; Janssen Pharmaceutica NV; Ameriks, Michael K.; Laforteza, Brian Ngo; Savall, Brad M.; Wade, Warren Stanfield; Meyer, Stephen Todd; Gyuris, Mario; (39 pag.)US2018/111925; (2018); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem