Adding a certain compound to certain chemical reactions, such as: 7477-63-6, name is 7-Chloroisatin, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7477-63-6, HPLC of Formula: C8H4ClNO2
General procedure: To a solution of isatin derivative (0.68mmol, 1.0eq) in DMF (4mL) was added K2CO3 (0.68mmol, 1.0eq) at room temperature, the mixture was stirred for about 30min, and then the propargyl bromide (0.75mmol, 1.1eq) was added dropwise. The mixture was stirred for 6-10hat room temperature depending on the isatin derivative used. Upon completion, EtOAc and H2O were added. The aqueous layer was extracted with EtOAc; the combined organic layers were washed with H2O for several times to remove the DMF, and then washed with brine, dried over MgSO4 and evaporated to give the products. Brown solid, yield: 88%, m. p.: 151.7-152.4C, Rf=0.47(petroleum ether/ethyl acetate=2/1). 1H NMR (400MHz, CDCl3) delta 7.67-7.54 (m, 2H), 7.22-7.09 (m, 1H), 4.93 (d, J=2.5Hz, 2H), 2.33 (t, J=2.5Hz, 1H).13C NMR (100MHz, CDCl3) delta 181.76, 157.88, 145.28, 140.55, 125.21, 124.18, 120.60, 117.95, 77.50, 72.94, 31.84
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 7-Chloroisatin, and friends who are interested can also refer to it.
Reference:
Article; Yu, Bin; Qi, Ping-Ping; Shi, Xiao-Jing; Huang, Ruilei; Guo, Hao; Zheng, Yi-Chao; Yu, De-Quan; Liu, Hong-Min; European Journal of Medicinal Chemistry; vol. 117; (2016); p. 241 – 255;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem