In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 102359-00-2, name is 2-Oxoindoline-5-carboxylic Acid belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 102359-00-2
[Example 6] (3E)-3-((5-((E)-(1-acetyl-2-oxoindolin-3-ylidene)methyl)furan-2-yl)methylene)-2-oxoindoline-5-carboxylic acid (5) 5-carboxyindolin-2-one (1 equivalent), 3-((5-formylfuran-2-yl)methylene)-N-acetyl-2-oxoindoline (1.2 equivalents) and piperidine (0.2 equivalent) were dissolved in ethanol such that 1 mL of ethanol was used per 1 mumol of the total amount of the compounds, and the resulting mixture was stirred at room temperature for 2 hours. After completion of the reaction, the resulting precipitate was collected by filtration, washed with cooled ethanol several times and dried, whereby a target compound was obtained. 1H-NMR (d6-DMSO, 400 Mz): 9.41 (s, 1H), 9.39 (s, 1H), 8.42 (d, J= 3.91 Hz, 1H), 8.32 (d, J= 3.91 Hz, 1H), 8.07 (s, 1H), 7.98 (s, 1H), 7.92 (d, J= 8.05 Hz, 1H), 7.82 (d, J= 8.05 Hz, 1H), 7.60 (s, 1H), 7.55 (dd, J= 8.21 Hz, 1.72 Hz, 1H), 7.36 (d, J= 7.22 Hz, 1H), 7.26 (d, J= 7.22 Hz, 1H), 6.87 (m, 1H), 2.66 (s, 3H), MS m/z: 440(M)+
The synthetic route of 102359-00-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Theravalues Corporation; EP2130829; (2009); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem