In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 446292-08-6 as follows. Computed Properties of C22H19N3O6
10 g (S)-2-((2-oxo-3-(4-(3-oxo-morpholino)phe- nyl)oxazolidin-5-yl)methyl)isoindoline- i ,3-dione of Formula (I), 70 ml methanol and 60 ml monomethyl amine were added to REF at 25 C. to 35 C. The reaction was heated to 60 C. to 65 C. for i-2 hours. To the reaction mass L (+)- mandelic acid (3.6 g) was added and maintained for 30 minutes. The reaction mass was cooled to 45 to 50 C. and maintained for 30 minutes. The reaction mass was cooled to 25 to 35 C. and maintained for 30 minutes. The product was filtered and washed with methanol (50 mlx2) afforded the L(+)-mandelate salt of(S)-4-(4-(5-(aminomethyl)-2-oxo-ox- azolidin-3-yl)phenyl)morpholin-3-one of Formula (JM).
According to the analysis of related databases, 446292-08-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; CADILA HEALTHCARE LIMITED; Dwivedi, Shriprakash Dhar; Prasad, Ashok; Pal, Daya Ram; Sharma, Mukul Hari Prasad; Jain, Kuldeep Natwarlal; Patel, Naitik Bharatbhai; US2014/378682; (2014); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem