Related Products of 18711-13-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 18711-13-2 as follows.
In these schemes, ketone (4.0 equv.) and a catalytic amount of diethylamine (10 drops) are added to a solution of substituted isatin (1.0 equv.) in methanol (5 mL). The mixture is stirred at room temperature until starting material (substituted isatin) disappears completely. The resulting solution is concentrated and applied to flash chromatography eluting with hexane / ethyl acetate to afford pure product in quantitative yield. Further purification is done by recrystallization with hexane / ethyl acetate.; 4,7-Dichloro-3-[2-(4-chlorophenyl-2-oxoethyl)]-3-hydroxyI-l,3-dihydroindol-2-one (YK-4-275): white solid; mp 194-196 0C; 1H NMR (DMSO, 400 MHz) delta 10.96 (s, IH), 7.93 (d, 2H, J = 8.8 Hz), 7.57 (d, 2H, J = 8.8 Hz), 7.30 (d, IH, J = 8.8 Hz), 6.90 (d, IH5 J = 8.8 Hz), 6.47 (s, IH), 4.36 (d, IH, J= 18.4 Hz), 3.71 (d, IH5 J= 18.0 Hz).
According to the analysis of related databases, 18711-13-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GEORGETOWN UNIVERSITY; WO2008/83326; (2008); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem