Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4702-13-0, name is N-Phthaloylglycine, A new synthetic method of this compound is introduced below., COA of Formula: C10H7NO4
(a) Preparation of 1,3-dihydro-1,3-dioxo-2H-isoindole-2-acetyl chloride STR10 A solution of 1,3-dihydro-1,3-dioxo-2H-isoindole-2-acetic acid (7.00 g) and thionyl chloride (12 mL) was stirred at reflux under nitrogen for one hour. The thionyl chloride was distilled from the reaction, and the resulting crude product was further purified by distillation via a kugelrohr apparatus (BUCHI, Flawil, Switzerland). [Bp: 160-180 C. (oven temperature) at 10 mm Hg.]The yield of the title compound was 6.88 grams (90.2%). The structure of the title compound, and of all of the compounds synthesised in each of the subsequent examples, was confirmed by 1 H NMR.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; G. D. Searle & Co.; US5212169; (1993); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem