Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 20780-72-7, name is 4-Bromoisatin, A new synthetic method of this compound is introduced below., HPLC of Formula: C8H4BrNO2
General procedure: To a solution of compound 3 (1.0 mmol) and substituted isatin (1.0 mmol) in ethanol, 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) (2.0 mmol) was added. The reaction mixture was stirred at room temperature for about 1 h. The solvent was removed and CH2Cl2 was added, the organic phase was washed with water and brine, dried over Na2SO4. After removal of the solvent, the residue was purified by silica gel chromatography using acetone/petroleum ether (1/2) as the eluent to give the corresponding steroidal pyran?oxindole hybrids.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Yu, Bin; Qi, Ping-Ping; Shi, Xiao-Jing; Shan, Li-Hong; Yu, De-Quan; Liu, Hong-Min; Steroids; vol. 88; (2014); p. 44 – 52;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem