Reference of 3485-84-5, The chemical industry reduces the impact on the environment during synthesis 3485-84-5, name is N-Vinylphthalimide, I believe this compound will play a more active role in future production and life.
General procedure: General procedure B: To a dried glass tube, Togni reagent 2 (99mg, 0.3mmol, 1.5equiv), (L3)CuBr (10mg, 0.02mmol, 0.1equiv) and CH3CN (1.0mL) were added under N2 atmosphere, followed by substrate 1 (0.2mmol, 1.0equiv) and TMSCN (54muL, 0.4mmol, 2.0equiv). After the reaction mixture was stirred at room temperature for 0.5h, the mixture was concentrated under vacuum. The residue was purified by column chromatography on silica gel with a gradient eluent of petroleum ether and ethyl acetate to afford the product. General procedure B: Pale yellow solid; 46.6mg, 87%; 1H NMR (400MHz, CDCl3): delta 7.94 (dd, J=5.2, 3.2Hz, 2H), 7.82 (dd, J=5.2, 3.2Hz, 2H), 5.54 (dd, J=8.4, 5.2Hz, 1H), 3.33-3.17 (m, 1H), 3.06-2.94 (m, 1H); 13C NMR (100MHz, CDCl3): delta 165.5, 135.1, 131.0, 124.3, 124.0 (q, J=276.3Hz), 114.0, 35.0 (q, J=30.0Hz), 33.9 (q, J=3.8Hz); 19F NMR (376MHz, CDCl3): delta -65.1 (t, J=10.0Hz); HRMS (EI), calcd. for C12H7F3N2O2 268.0460 [M]+, found 268.0456.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N-Vinylphthalimide, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Liang, Zhaoli; Wang, Fei; Chen, Pinhong; Liu, Guosheng; Journal of Fluorine Chemistry; vol. 167; (2014); p. 55 – 60;,
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