In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6780-38-7, name is 2-(1,3-Dioxoisoindolin-2-yl)acetyl chloride belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 2-(1,3-Dioxoisoindolin-2-yl)acetyl chloride
General procedure: A solution of acyl chloride (1.2-5 mmol) in anhydrous benzene (5 mL) was added dropwise to a solution of diimine (1 mmol) and triethylamine (0.152-0.606 g, 1.5-6 mmol) in toluene (10 mL). The resulting mixture was stirred at 80 C under nitrogen for 4-16 h, which was determined by TLC monitoring. The reaction mixture was then diluted with CH2C12 (20 mL) and subsequently washed with saturated aqueous NaHCO3 solution (20 mL) and brine (2¡Á10 mL). After dried over anhydrous Na2SO4 and removal of solvent, the residue was purified via recrystallization with EtOAc or a mixture of EtOAc and hexanes or via flash column chromatography (silica gel, a mixture of hexanes and EtOAc as eluent) to afford the product.
The synthetic route of 6780-38-7 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Wang, Zhixin; Chen, Ning; Xu, Jiaxi; Tetrahedron; vol. 67; 50; (2011); p. 9690 – 9699;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem