New downstream synthetic route of 15362-40-0

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 15362-40-0.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 15362-40-0, name is 1-(2,6-Dichlorophenyl)-2-indolinone, This compound has unique chemical properties. The synthetic route is as follows., Formula: C14H9Cl2NO

Example Vl; 1 -(2,6-dichloro-phenyl)-5-nitro-1 ,3-dihvdro-indol-2-one600 mg 1 -(2,6-dichloro-phenyl)-1 ,3-dihydro-indol-2-one are dissolved in 5 ml concentrated sulphuric acid and cooled to 00C . To this is added dropwise a solution of 160 mul concentrated nitric acid in 1 ml concentrated sulphuric acid.The mixture is stirred for 30 minutes and then added to 50 g ice. Then the mixture is stirred for 1 hour and the solid is suction filtered. After drying in vacuo the solid is chromatographed on silica gel (cyclohexane/ethyl acetate 70:30 to 20:80).Yield: 310 mg (44 % of theory)Mass spectrum (ESI+): m/z = 323 [M+H]+

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 15362-40-0.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; WO2009/16118; (2009); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem