Adding some certain compound to certain chemical reactions, such as: 496-12-8, name is Isoindoline, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 496-12-8. 496-12-8
Commercially available benzenesulfonylchloride 6 (500 mg, 2.12 mmol) was dissolved in CH2Cl2 (29 mL), treated with Et3N (0.89 mL, 6.4 mmol) and isoindoline (0.48 mL, 0.51 g, 4.2 mmol) and stirred at room temperature for 3 h. The organic layer was diluted with CH2Cl2, washed successively with 1N aqueous HCl and then dried over anhydrous sodium sulphate. Evaporation under vacuum of the organic solvent afforded a crude product which was purified by column chromatography over silica gel, to yield the sulfonamidic derivative.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of Isoindoline.
Reference:
Article; Granchi, Carlotta; Roy, Sarabindu; Mottinelli, Marco; Nardini, Elisa; Campinoti, Fabio; Tuccinardi, Tiziano; Lanza, Mario; Betti, Laura; Giannaccini, Gino; Lucacchini, Antonio; Martinelli, Adriano; MacChia, Marco; Minutolo, Filippo; Bioorganic and Medicinal Chemistry Letters; vol. 21; 24; (2011); p. 7331 – 7336;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem