These common heterocyclic compound, 61-70-1, name is 1-Methylindolin-2-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C9H9NO
To a dried round-bottomed flask equipped with a magnetic stir bar was added 1-methylindolin-2-one (0.74 g, 5 mmol), Lawesson?s Reagent (1.07 g, 2.65 mmol) in dry CH2Cl2 (3.60 mL). The reaction was held at the room temperature for 20 h, followed by concentration in vacuo. The solvent was evaporated under reduced pressure and the residue was purified by column chromatography to get 1-methylindoline-2-thione 1 (0.69g, 85% bright yellow solid).
This is the end of this tutorial post, and I hope it has helped your research about 61-70-1.
Reference:
Article; Zhou, Shiping; Xiao, Genhua; Liang, Yun; Tetrahedron Letters; vol. 58; 4; (2017); p. 338 – 341;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem