Safety of tert-Butyl 5-aminoindoline-1-carboxylate,Chemistry involves the study of all things chemical – chemical processes, chemical compositions and chemical manipulation – in order to better understand the way in which materials are structured, how they change and how they react in certain situations.
The 1-tert-butoxy-carbonyl-5-amino indoline (3g, 14mmol) dissolved in water (3 ml) in, cooling to-5-0 C degrees, dropping sodium nitrite (1.16g, 16 . 8mmol) of water (3 ml) solution, 0 C stirring for 30 minutes, a diazo reaction liquid obtained, the spare; sodium acetate (2.64g, 32 . 2mmol) dissolved in water (3 ml) in, by adding 2-chloro acetyl ethyl acetate (2.3g, 14 . 0mmol) second grade fat of the acetic acid (5 ml) solution, cooled to 0 C, spare the dropping of a diazo reaction solution, 0 C reaction 1 hour. Adding water to the reaction solution (50 ml), ethyl acetate (50 ml × 3) extraction, combined organic phase, the organic phase with water (50 ml × 2) washing, dry anhydrous sodium sulfate, concentrated, the title compound ethyl 2-chloro-2-(2-(indolin-5-yl)hydrazono)acetate (25B), yellow solid (1.2g, yield 32%).
According to the analysis of related databases, 129487-92-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SICHUAN HAISCO PHARMACEUTICAL CO LTD; WEI, YONGGANG; QIU, GUANPENG; LEI, BAILIN; LU, YONGHUA; (120 pag.)CN104395312; (2016); B;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem