Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 141452-01-9, name is Methyl indoline-5-carboxylate, A new synthetic method of this compound is introduced below., Quality Control of Methyl indoline-5-carboxylate
A glass microwave reaction vessel was charged with methyl indoline-5-carboxylate (0.06 g, 0.339 mmol), 2-cliloro-4-methyipyrimidine (0.054 g, 0.423 mmol),racemic-2,2′-bis(diphenyTphosphino)- I,’-tainaphthyl (0.032 g, 0.051 mmol), palladium (ii) acetate (7.60 mg, 0.034 mmol) and cesium carbonate (0.221 g, 0.677 mmol) in tetrahydrofuran (1.7 ml). The reaction mixture w’as purged with N2 and heated in a microwave reactor at 110 C for 10 min. LCMS showed desired product. The reaction mixture was diluted with water and extracted with DCM. The organic extract was washed with saturated NaCl and dried over MgSCb. The solution was filtered and concentrated in vacuo to yield cmde product which was used for next step directly m/z: 270.2 [M+l]
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; AMGEN INC.; CARMOT THERAPEUTICS, INC.; BUTLER, John R.; ERLANSON, Daniel; GRACEFFA, Russell; IWIG, Jeffrey; JEONG, Joon Won; WHITE, Ryan D.; WU, Yongwei; YI, Shuyan; BANERJEE, Abhisek; MCFARLAND, Jesse M.; ZHENG, Xiao Mei; (307 pag.)WO2020/36940; (2020); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem