Introduction of a new synthetic route about 84575-27-9

The chemical industry reduces the impact on the environment during synthesis 7-Methoxyindoline-2,3-dione. I believe this compound will play a more active role in future production and life.

Related Products of 84575-27-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 84575-27-9, name is 7-Methoxyindoline-2,3-dione, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A mixture of PPh3 (1.1 eq), isatin or 5-nitro-isatin (1.0 eq), andsubstituted 2-bromoacetate (1.1 eq) was heated at 80 C, then morpholine (1.1 eq) was added. After the reaction completion and cooling to the room temperature, the mixture was diluted with water, extracted with CH2Cl2, and the organic phase was dried over sodium sulfate. The solvent was removed under reduced pressure and the residue was purified by chromatography using Petroleum ether/Ethyl acetate to give the target compounds.

The chemical industry reduces the impact on the environment during synthesis 7-Methoxyindoline-2,3-dione. I believe this compound will play a more active role in future production and life.

Reference:
Article; Song, Zhuang; Chen, Cai-Ping; Liu, Jun; Wen, Xiaoan; Sun, Hongbin; Yuan, Haoliang; European Journal of Medicinal Chemistry; vol. 124; (2016); p. 809 – 819;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem