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General procedure: To a stirred mixture of isatins (1mmol) and malononitrile/ethyl cyanoacetate (1mmol) in methanol (3ml), was added piperidine (10molpercent) and the reaction mixture was stirred at room temperature for 10min. Then 5,7-dihydroxy-4-methyl-2H-chromen-2-one (1mmol) was added to it. The resulting mixture was stirred at reflux until the reaction was completed as indicated by TLC. The resulting precipitate was treated with dilute HCl and washed with water to afford the pure product for analysis.
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Reference:
Article; Pal, Suman; Khan, Md. Nasim; Karamthulla, Shaik; Choudhury, Lokman H.; Tetrahedron Letters; vol. 56; 2; (2015); p. 359 – 364;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem