Formula: C9H6BrNO2, Chemical engineers ensure the efficiency and safety of chemical processes, adapt the chemical make-up of products to meet environmental or economic needs, and apply new technologies to improve existing processes.
Example 14: 6-((R)-5-{2-[((R5)-8-methoxy-l,2-dihydro-3-oxa-5,9-diaza- cyclopenta[fl]naphthalen-l-ylmethyl)-amino]-ethyl}-2-oxo-oxazolidin-3-yl)- 4H-benzo [ 1 ,4] thiazin-3-one:; 14.L rac-3-( 1 ,3-dioxo- 1 ,3-dihydro-isoindol-2-yl)-2-(3-fluoro-6-methoxy- [ 1 ,5] naphthyridin-4-yl)-propionic acid ethyl ester:; A solution of (3-fluoro-6-methoxy-[l,5]naphthyridin-4-yl)-acetic acid ethyl ester (6.78 g; prepared in analogy to the corresponding methyl ester described in WO 2007/122258) in TEtaF (30 niL) was added dropwise at -78C to a solution of LiEtaMDS (31 mL; IM in TEtaF) diluted in TEtaF (2O mL). After stirring for I h at -78C a solution of Lambda/-(bromomethyl)phthalimide (7.40 g) in TEtaF (30 mL) was added dropwise and the mixture was stirred for an additional 1 h at -78C and then overnight at rt. The yellow solution was quenched with N HCl (280 mL) and extracted with DCM. The combined org. layers were washed with H2O, dried over MgSO4, concentrated and purified by CC (Hept/EA 1 : 1), affording a light yellow foam (5.49 g; 51% yield). MS (ESI, m/z): 424.2 [M+H+].
The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.I hope my blog about 5332-26-3 is helpful to your research.
Reference:
Patent; ACTELION PHARMACEUTICALS LTD; HUBSCHWERLEN, Christian; RUEEDI, Georg; SURIVET, Jean-Philippe; ZUMBRUNN ACKLIN, Cornelia; WO2010/15985; (2010); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem