Adding some certain compound to certain chemical reactions, such as: 39755-95-8, name is 5-Methoxyisatin, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39755-95-8. 39755-95-8
Synthesis of l -Benzyl-5-methoxyindolin-2-one[00143] A stirred solution of 5-methoxyisatin (5.0 g, 28 mmol) in dry DMF (40 mL) was cooled in an ice bath before addition of sodium hydride (60 wt% in mineral oil, 1.7 g, 42 mmol) slowly, the dark red solution turning quickly black. After stirring for 20 min, BnBr (3.7 mL, 31 mmol) was added to the reaction mixture by syringe and the resulting mixture was stirred for 1 h. Water (150 mL) was added with stirring, and the resulting dark red precipitate collected by filtration and washed with water to give l-benzyl-5- methoxyindoline-2,3-dione as a dark red solid (6.1 g, 81%). NMR (400 MHz, CDC13) delta 7.39-7.31 (m, 5H), 7.17 (s, 1H), 7.03 (d, J = 8.1 Hz, 1H), 6.68 (d, J = 8.6 Hz, 1H), 4.92 (s, 2H), 3.79 (s, 3H). MS ESI 268.1 [M + H]+, calcd for [C16H13N03+ Hf 268.09.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 5-Methoxyisatin.
Reference:
Patent; UNIVERSITY HEALTH NETWORK; SAMPSON, Peter Brent; LIU, Yong; LI, Sze-Wan; FORREST, Bryan T.; PAULS, Heinz W.; EDWARDS, Louise G.; FEHER, Miklos; PATEL, Narendra Kumar B.; LAUFER, Radoslaw; PAN, Guohua; WO2011/123946; (2011); A1;,
Indoline – Wikipedia,
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