Adding a certain compound to certain chemical reactions, such as: 15937-07-2, name is 5,6-Dimethoxyindoline, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 15937-07-2, Product Details of 15937-07-2
The experimental steps and operations are: at room temperature,18 g of Compound 2 was dissolved in 200 mL of acetonitrile, and the mixture was vigorously stirred in an environment where the container was exposed to air or oxygen, and the reaction was continued.The TLC tracks the reaction until the material completely disappears, which takes approximately 16-24 hours.The crude product was concentrated under reduced pressure on a rotary evaporator, and purified using silica gel column chromatography eluting with petroleum ether ethyl acetate (90:10, v/v).Obtaining Compound 3 as a colorless crystal; placing a single crystal in the receiving bottle. The weight of the compound 3 was 11.5 g, and the yield was 71% (the total yield of the two-step reaction).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5,6-Dimethoxyindoline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Yantai Liudi Pharmaceutical Technology Co., Ltd.; Yang Jiade; Wang Xiujie; Fan Yulong; Qu Wenchao; Chen Tingting; (14 pag.)CN108484471; (2018); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem