Reference of 5181-35-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5181-35-1, name is 2-(2-Bromoethoxy)isoindoline-1,3-dione, This compound has unique chemical properties. The synthetic route is as follows.
To a solution of 2-(2-bromoethoxy)isoindoline- l,3-dione (20 g, 74 mmol, prepared according to the procedure described in step 1 of preparation 38), (lH-tetrazol- 5-ylmethyl)-carbamic acid tert-butyX ester (7.66 g, 74 mmol, prepared as per procedure described in step 2 of preparation 19) in dimethylformamide (100 ml) was added cesium carbonate (24.13 g, 74 mmol) lot wise under stirring at 25 C. After 16 hours, the reaction mixture was filtered and filtrate was slowly poured into chilled water (700 ml) and stirred for 30 minutes. The precipitated compound was filtered and washed with water (100 ml). The solid compound was dried at 35C for 2 hours under high vacuum, to provide 16 g of tert-butyX [(2-{2-[(l,3-dioxo- l,3-dihydro-2H- isoindol-2-yl)oxy]ethyl}-2H-tetrazol-5-yl)methyl] carbamate in 55% yield. Analysis: Mass: 389.4 (M+l); for Molecular weight: 388 and Molecular formula: Ci7H20N6O5.
The chemical industry reduces the impact on the environment during synthesis 2-(2-Bromoethoxy)isoindoline-1,3-dione. I believe this compound will play a more active role in future production and life.
Reference:
Patent; WOCKHARDT LIMITED; TADIPARTHI, Ravikumar; PATIL, Vijaykumar Jagdishwar; DEKHANE, Deepak; SHAIKH, Mohammad Usman; BIRAJDAR, Satish; DOND, Bharat; PATEL, Mahesh Vithalbhai; (100 pag.)WO2017/81615; (2017); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem