Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 675109-26-9, name is 6-Bromoisoindolin-1-one, A new synthetic method of this compound is introduced below., Recommanded Product: 675109-26-9
[1532] to a solution of 6-bromoisoindolin-1-one (0.5 g, 2.36 mmol) in acetone (20 ml) was added bnbr (605 mg, 3.54 mmol, 0.420 ml),Cs2CO3 (1.92 g, 5.90 mmol) and 18- crown-6 (62 mg, 235.80 umol), then the mixture was stirred at 70 C for 16h. The reaction mixture was concentrated to remove solvent, then diluted with water (50 ml) and extracted with ea (40 ml x 2), and the organic layers were dried over Na2SO4, filtered and concentrated to give a residue. The residue was purified by flash silica gel chromatography (isco; 12 g sepaflash silica flash column, eluent of 0-20% ethyl acetate/petroleum ethergradient 30 ml/min). Compound 378a (0.46 g, yield: 59.5%) was obtained as white solid. 1H NMR (400mhz, CDCl3) delta 8.02 (d, j = 1.8 hz, 1h), 7.63 (dd, j = 1.9, 8.0 hz, 1h), 7.39 – 7.16 (m, 6h), 4.79 (s, 2h), 4.21 (s, 2h). MS (ESI) m/z (M+H)+ 302.0.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; BLADE THERAPEUTICS, INC.; BUCKMAN, Brad, Owen; YUAN, Shendong; ADLER, Marc; EMAYAN, Kumaraswamy; MA, Jingyuang; (687 pag.)WO2018/64119; (2018); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem