Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 446292-08-6, name is (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione, A new synthetic method of this compound is introduced below., Recommanded Product: 446292-08-6
Add 4 kg of N-methylpyrrolidone to a 10 L reaction flask.Add 1.0kg of compound (II), add 0.3kg of 80% hydrazine hydrate, stir and heat.The reaction was stirred at 90 C for 4 h. The reaction solution was cooled to 45 ± 5 C,Add about 0.7kg of sulfuric acid, add the reaction, and cool the reaction solution to 5±5C for 1h~1.5h.Filtration, filter cake washed with N-methylpyrrolidone, ethanol,Transfer the wet product to the blast oven,The internal temperature of the oven was controlled to dry at 50-55 C for 16 ± 1 hour to obtain a white solid.Yield: 92%, product purity (HPLC): 99.5%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Changzhou Pharmaceutical Factory Co., Ltd.; Guo Yijie; Jin Xiaofeng; Shao Zhichun; (13 pag.)CN110156768; (2019); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem