Synthetic Route of 2058-72-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2058-72-2 as follows.
General procedure: Isatin (10 mmol), 2,2,2-trifluoroethylamine hydrochloride (15 mmol) and p-toluenesulfonic acid (0.5mmol) were suspended in toluene (10 mL) in a two-neck flask with a water separator and a condenser.The mixture was then heated to separate the water until complete disappearance of the starting materials.After cooling to room temperature, the mixture was washed with a small quantity of saturated NaHCO3solution and dried by Na2SO4, After evaporation of the organic solvent, the crude residue was purified byflash chromatography (silica gel, hexane/EtOAc) and afforded the resulting ketimine.
According to the analysis of related databases, 2058-72-2, the application of this compound in the production field has become more and more popular.
Reference:
Article; Huang, Wei-Jie; Chen, Qing; Zhu, Wen-Run; Lin, Ning; Long, Xian-Wen; Pan, Wei-Gao; Weng, Jiang; Lu, Gui; Heterocycles; vol. 94; 5; (2017); p. 879 – 893;,
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