In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3339-73-9 as follows. Quality Control of 3-(1,3-Dioxoisoindolin-2-yl)propanoic acid
A solution of 28 (2.000 g, 9.12 mmol), DPPA (1 .966 mL, 9.12 mmol, 1 eq) and TEA (2.543 ml, 2 eq, 1 8.25 mmol) in dry toluene (60 mL) was stirred at rt, under a nitrogen atmosphere. After disappearance of starting materials by TLC (approximately 1 hour), the mixture was refluxed to promote conversion to the isocyanate. After evolution of nitrogen gas had ceased, the reaction mixture was split into half (by volume). 2-aminophenol (747 mg, 1.5 eq, 6.84 mmol) was added to one half of the isocyanate solution and stirred under reflux for 16 hours. On cooling to rt a yellow precipitate formed, which was collected by filtration (suction) and washed with EtOAc. On drying, 867 mg of pale yellow solid was obtained requiring no further purification.
According to the analysis of related databases, 3339-73-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; THE UNIVERSITY OF NOTTINGHAM; MISTRY, Shailesh; DARAS, Etienne; FROMONT, Christophe; JADHAV, Gopal; FISCHER, Peter Martin; KELLAM, Barrie; HILL, Stephen John; BAKER, Jillian Glenda; WO2012/4549; (2012); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem