2913-97-5, name is N-(2-Oxoethyl)phthalimide, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 2913-97-5
Under a nitrogen atmosphere, to a mixture of NaH (560 mg, 22 mmol) and anhydrous THF (90 mL), a solution of diethyle(2-oxopropyl)phosphonate (4.27 g, 22 mmol) in THF (60 mL) was added over 10 min. The resulting solution was stirred at r.t. for 1 h. Then Compound 2 (6.24 g, 33 mmol) was dissolved in THF (30 mL) and was added dropwise to the above solution. The reaction mixture was stirred at r.t. for a further 3 h. The reaction was quenched with H2O, and THF was removed in vacuo. The residue was then extracted with CH2Cl2 and the combined organic layer was washed with 1N HCl and saturated NaHCO3, dried over Na2SO4. The solvent was evaporated and the residue was purified by silica gel column chromatography with Hexane/EtOAc (1:1) to provide Compound 3 (4.6 g, 20 mmol, 60percent) as a white solid. 1H NMR (CDCl3, 400 MHz) delta 7.91 (m, 2H), 7.79 (m, 2H), 6.81-6.74 (m, 1H), 6.16-6.11(dt, J=1.6, 16.0 Hz, 1H), 4.49 (dd, J=1.6, 4.8 Hz, 2H), 2.27 (s, 3H); 13C NMR (CDCl3, 100 MHz): delta 197.7, 167.7, 139.7, 134.4, 131.9, 131.8, 123.7, 123.6, 38.3, 27.2; MS (ESI, positive) m/z calcd. for C13H12NO3 [M+H]+: 230, found: 230.
The synthetic route of 2913-97-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; UNIVERSITY OF DELAWARE; Zhuang, Zhihao; Li, Guorui; (15 pag.)US9605297; (2017); B2;,
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